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Tytuł:
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Evaluation of ICAM-1 rs5498 and rs3093030 Polymorphisms in Chinese Patients with Colorectal Cancer.
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Autorzy:
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Qiu Z; Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Xie Z; Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Qin R; Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Chen M; Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
He H; Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Zhang Z; Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Wang Y; Department of Oncology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Hong M; Center for Foreign Language Education Research, Zhejiang International Studies University, Hangzhou, Zhejiang, China.
Tang W; Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Xi Y; Department of Geriatrics, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Zhang S; Department of General Surgery, Changzhou No. 3 People's Hospital, Changzhou, Jiangsu, China.
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Źródło:
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DNA and cell biology [DNA Cell Biol] 2021 Feb; Vol. 40 (2), pp. 384-392. Date of Electronic Publication: 2020 Dec 21.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: [New York, NY] : Mary Ann Liebert, [c1990-
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MeSH Terms:
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Polymorphism, Single Nucleotide*
Asian People/*genetics
Colorectal Neoplasms/*genetics
Intercellular Adhesion Molecule-1/*genetics
Case-Control Studies ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Middle Aged
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Contributed Indexing:
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Keywords: ICAM-1; colorectal cancer; polymorphism; risk
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Substance Nomenclature:
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126547-89-5 (Intercellular Adhesion Molecule-1)
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Entry Date(s):
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Date Created: 20201221 Date Completed: 20210226 Latest Revision: 20221207
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Update Code:
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20240105
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DOI:
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10.1089/dna.2020.6089
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PMID:
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33347388
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Colorectal cancer (CRC) is a common cancer threatening human health. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays a key role in carcinogenesis and previous studies have suggested that ICAM-1 single-nucleotide polymorphisms (SNPs) are predicted to increase the risk of CRC. However, the relationship of ICAM-1 SNPs with CRC susceptibility was controversial. We conducted a case-control study to clarify the association of ICAM-1 SNPs (rs5498 and rs3093030) with the CRC risk. A total of 1003 CRC patients and 1303 controls were recruited to determine ICAM-1 SNPs (rs5498 and rs3093030) by SNPscan method. In the case-control study, we found that ICAM-1 rs5498 polymorphism did not influence CRC risk (AG vs. AA: adjusted p = 0.179; GG vs. AA: adjusted p = 0.281, AG+GG vs. AA: adjusted p = 0.398; GG vs. AA+AG: adjusted p = 0.153), and ICAM-1 rs3093030 polymorphism did not influence CRC risk (CT vs. CC: adjusted p = 0.841; TT vs. CC: adjusted p = 0.175, CT+TT vs. CC: adjusted p = 0.574 and TT vs. CC+TT: adjusted p = 0.180). In a subgroup of age >61, ICAM-1 rs5498 decreased the risk of CRC ( p = 0.047). Multivariate analysis revealed that smoking ( p = 0.002; odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.18-2.63), alcohol intake ( p < 0.001; OR: 1.99, 95% CI: 1.31-3.05), and body mass index <24 ( p < 0.001; OR: 1.55, 95% CI: 1.06-2.26) increased the risk of CRC. Our findings showed that ICAM-1 rs3093030 was not correlated with the susceptibility of CRC, and ICAM-1 rs5498 increased the risk of CRC in the subgroup of age ≥61. In the future, larger and ethnically homogeneous populations are needed to confirm our results.
