Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH.

Tytuł:
GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH.
Autorzy:
Kim KH; GI Innovatioin, Inc., Tera Tower, Songpa-daero 167, Songpa-gu, Seoul 05855, South Korea. Electronic address: .
Lee MS; Severance Biomedical Science Institute and Dept. of Internal Medicine, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul 03722, South Korea. Electronic address: .
Źródło:
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Mar; Vol. 1865 (3), pp. 129834. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Original Publication: Amsterdam : Elsevier
MeSH Terms:
Aging/*genetics
Growth Differentiation Factor 15/*genetics
Mitochondrial Myopathies/*genetics
Muscular Atrophy/*genetics
Non-alcoholic Fatty Liver Disease/*genetics
Obesity/*genetics
Aging/metabolism ; Animals ; Disease Models, Animal ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/genetics ; Gene Expression Regulation ; Growth Differentiation Factor 15/metabolism ; Growth Differentiation Factor 15/therapeutic use ; Humans ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Myopathies/metabolism ; Mitochondrial Myopathies/pathology ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/metabolism ; Obesity/pathology ; Unfolded Protein Response
Contributed Indexing:
Keywords: ER; GDF15; Metabolic diseases; Mitochondria; NASH; Stress
Substance Nomenclature:
0 (GDF15 protein, human)
0 (Growth Differentiation Factor 15)
Entry Date(s):
Date Created: 20201228 Date Completed: 20210414 Latest Revision: 20210414
Update Code:
20240105
DOI:
10.1016/j.bbagen.2020.129834
PMID:
33358864
Czasopismo naukowe
Background: Mitochondria is a key organelle for energy production and cellular adaptive response to intracellular and extracellular stresses. Mitochondrial stress can be evoked by various stimuli such as metabolic stressors or pathogen infection, which may lead to expression of 'mitokines' such as growth differentiation factor 15 (GDF15).
Scope of Review: This review summarizes the mechanism of GDF15 expression in response to organelle stress such as mitochondrial stress, and covers pathophysiological conditions or diseases that are associated with elevated GDF15 level. This review also illustrates the in vivo role of GDF15 expression in those stress conditions or diseases, and a potential of GDF15 as a therapeutic agent against metabolic disorders such as NASH.
Major Conclusions: Mitochondrial unfolded protein response (UPRmt) is a critical process to recover from mitochondrial stress. UPRmt can induce expression of secretory proteins that can exert systemic effects (mitokines) as well as mitochondrial chaperons. GDF15 can have either protective or detrimental systemic effects in response to mitochondrial stresses, suggesting its role as a mitokine. Mounting evidence shows that GDF15 is also induced by stresses of organelles other than mitochondria such as endoplasmic reticulum (ER). GDF15 level is increased in serum or tissue of mice and human subjects with metabolic diseases such as obesity or NASH. GDF15 can modulate metabolic features of those diseases.
General Significance: GDF15 play a role as an integrated stress response (ISR) beyond mitochondrial stress response. GDF15 is involved in the pathogenesis of metabolic diseases such as NASH, and also could be a candidate for therapeutic agent against those diseases.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies