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Tytuł:
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Deficiency of mannose-binding lectin is a risk of Pneumocystis jirovecii pneumonia in a natural history cohort of people living with HIV/AIDS in Northern Thailand.
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Autorzy:
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Yanagisawa K; Department of Hematology, Gunma University Hospital, Maebashi, Japan.; Infection Control and Prevention Center, Gunma University Hospital, Maebashi, Japan.
Wichukchinda N; Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Tsuchiya N; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yasunami M; Department of Laboratory Medicine, Saga-Ken Medical Centre Koseikan, Saga, Japan.
Rojanawiwat A; Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Tanaka H; HLA Foundation Laboratory, Kyoto, Japan.
Saji H; HLA Foundation Laboratory, Kyoto, Japan.
Ogawa Y; Department of Hematology, Gunma University Hospital, Maebashi, Japan.
Handa H; Department of Hematology, Gunma University Hospital, Maebashi, Japan.
Pathipvanich P; Day Care Centre, Lampang Hospital, Lampang, Thailand.
Ariyoshi K; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Sawanpanyalert P; Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
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Źródło:
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PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0242438. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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AIDS-Related Opportunistic Infections/*epidemiology
Mannose-Binding Lectin/*deficiency
Pneumocystis carinii/*isolation & purification
Pneumonia, Pneumocystis/*epidemiology
AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/genetics ; AIDS-Related Opportunistic Infections/microbiology ; Adolescent ; Adult ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genotyping Techniques ; Humans ; Immunity, Innate/genetics ; Incidence ; Male ; Mannose-Binding Lectin/genetics ; Mannose-Binding Lectin/immunology ; Middle Aged ; Pneumocystis carinii/immunology ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/genetics ; Pneumonia, Pneumocystis/microbiology ; Prospective Studies ; Risk Factors ; Thailand/epidemiology ; Young Adult
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Substance Nomenclature:
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0 (MBL2 protein, human)
0 (Mannose-Binding Lectin)
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Entry Date(s):
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Date Created: 20201228 Date Completed: 20210119 Latest Revision: 20210119
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Update Code:
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20240105
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PubMed Central ID:
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PMC7757797
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DOI:
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10.1371/journal.pone.0242438
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PMID:
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33362211
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Background: Mannose-binding lectin (MBL) plays a pivotal role in innate immunity; however, its impact on susceptibility to opportunistic infections (OIs) has not yet been examined in a natural history cohort of people living with HIV/AIDS.
Methods: We used archived samples to analyze the association between MBL expression types and risk of major OIs including Pneumocystis jirovecii pneumonia (PCP), cryptococcosis, talaromycosis, toxoplasmosis, and tuberculosis in a prospective cohort in Northern Thailand conducted from 1 July 2000 to 15 October 2002 before the national antiretroviral treatment programme was launched.
Results: Of 632 patients, PCP was diagnosed in 96 (15.2%) patients, including 45 patients with new episodes during the follow-up period (1006.5 person-years). The total history of PCP was significantly associated with low MBL expression type: high/intermediate (81/587, 13.8%), low (10/33, 30.3%) and deficient (5/12, 41.7%) (p = 0.001), whereas the history of other OIs showed no relation with any MBL expression type. Kaplan-Meier analysis (n = 569; log-rank p = 0.011) and Cox's proportional hazards model revealed that deficient genotype dramatically increased the risk of PCP, which is independent upon sex, age, CD4 count, HIV-1 viral load and hepatitis B and C status (adjusted hazard ratio 7.93, 95% confidence interval 2.19-28.67, p = 0.002).
Conclusions: Deficiency of MBL expression is a strong risk factor determining the incidence of PCP but not other major OIs.
Competing Interests: The authors have declared that no competing interests exist.
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