Factors affecting the acceptance of deoxyguanosine-treated thymus allografts.

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Abstrakt

Tytuł:: Factors affecting the acceptance of deoxyguanosine-treated thymus allografts.
Autorzy:: Buckley G; Department of Anatomy, University of Birmingham Medical School, England.
Benson MT
Jenkinson EJ
Owen JJ
Źródło:: Transplantation [Transplantation] 1988 Jan; Vol. 45 (1), pp. 202-5.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Williams & Wilkins.
MeSH Terms:: Deoxyguanosine/*pharmacology
Graft Survival/*drug effects
Thymus Gland/*transplantation
Animals ; Dendritic Cells/drug effects ; Epithelium/immunology ; Female ; H-2 Antigens/immunology ; Lymphoid Tissue/drug effects ; Mice ; Mice, Inbred Strains/immunology ; Organ Culture Techniques ; Spleen/transplantation ; Thymus Gland/drug effects ; Thymus Gland/immunology ; Transplantation, Homologous
Substance Nomenclature:: 0 (H-2 Antigens)
G9481N71RO (Deoxyguanosine)
Entry Date(s):: Date Created: 19880101 Date Completed: 19880224 Latest Revision: 20190713
Update Code:: 20240104
DOI:: 10.1097/00007890-198801000-00041
PMID:: 3336916
: Czasopismo naukowe

dGuo-treated mouse embryo thymus lobes depleted of lymphoid and dendritic cells are not rejected by normal allogeneic mice despite expression of class I and class II major histocompatibility (MHC) antigens on thymic epithelial cells. Our results suggest that host mice are not tolerant to donor antigens, but treated lobes survive because thymic epithelial cells are not immunogenic. Multiple grafts of dGuo-treated lobes are rejected perhaps because numbers of residual dendritic cells reach a threshold necessary for priming. Mice previously primed by injection of spleen cells reject dGuo-treated thymus lobes, and crossreactions between major and minor histocompatibility antigens can be demonstrated. The acceptance of dGuo-treated thymus allografts by normal mice provides a system for investigating the requirements for priming.

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