Effects of neuro-adaptive electrostimulation therapy on pain and disability in fibromyalgia: A prospective, randomized, double-blind study.

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Abstrakt

Tytuł:: Effects of neuro-adaptive electrostimulation therapy on pain and disability in fibromyalgia: A prospective, randomized, double-blind study.
Autorzy:: Udina-Cortés C; Institute Neurolife.
Fernández-Carnero J; Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, University Rey Juan Carlos.; La Paz Hospital Institute for Health Research (IdiPAZ).; Motion in Brains Research Group, Institute of Neuroscience and Movement Sciences, Centro Superior de Estudios Universitarios La Salle, Universidad Autonoma de Madrid.
Romano AA; Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, University Rey Juan Carlos.
Cuenca-Zaldívar JN; School of Health Sciences, University Francisco de Vitoria, Madrid, Spain.
Villafañe JH; IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Castro-Marrero J; Vall d'Hebron Hospital Research Institute, Division of Rheumatology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Alguacil-Diego IM; Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, University Rey Juan Carlos.
Źródło:: Medicine [Medicine (Baltimore)] 2020 Dec 18; Vol. 99 (51), pp. e23785.
Typ publikacji:: Journal Article; Randomized Controlled Trial
Język:: English
Imprint Name(s):: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:: Electric Stimulation Therapy/*methods
Fibromyalgia/*therapy
Adult ; Analysis of Variance ; Cohort Studies ; Disabled Persons/psychology ; Double-Blind Method ; Electric Stimulation Therapy/standards ; Electric Stimulation Therapy/statistics & numerical data ; Female ; Fibromyalgia/complications ; Fibromyalgia/physiopathology ; Humans ; Middle Aged ; Pain/etiology ; Pain Management/methods ; Pain Measurement/methods ; Placebos/therapeutic use ; Prospective Studies ; Spain/epidemiology ; Surveys and Questionnaires ; Treatment Outcome
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Substance Nomenclature:: 0 (Placebos)
Entry Date(s):: Date Created: 20201229 Date Completed: 20210112 Latest Revision: 20210323
Update Code:: 20240105
PubMed Central ID:: PMC7748312
DOI:: 10.1097/MD.0000000000023785
PMID:: 33371148
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Background: To evaluate the effectiveness of non-invasive neuro-adaptive electrostimulation (NAE) therapy for treating chronic pain and disability in patients with fibromyalgia.
Method/design: A prospective, randomized, sham-controlled study was conducted in 37 women with fibromyalgia. Participants were randomly assigned to receive either active NAE (n = 20) or stimulation with a sham device (n = 17). Participants in the experimental arm received eight 30-minute sessions over 4 weeks (2 sessions per week). The sham group received eight 30-minute sessions of sham stimulation. Therapeutic effects on pain relief, disability, and quality of life were evaluated using outcome measures at baseline, at 4 weeks, and after 3 months' follow-up.
Results: The findings indicated a significant reduction of pain in the active NAE group compared with the sham group immediately post-intervention, with a difference on the Visual Analog Scale (VAS) of 3 points (P = .001), and at 3 months' follow-up (P = .02). There were significant intragroup differences between the groups (P < .05) at post-intervention. After the intervention, both groups presented significant reductions on the Fibromyalgia Impact Questionnaire (FIQ) with respect to baseline (P = .004), but not at the 3-month follow-up. In the conditioned pain modulation (CPM) in thumb variable we found significant differences between the groups at the 3-month follow-up (P = .02). No additional benefits for conditioned pain modulation and disability were observed between groups at the 3-month follow-up. Furthermore, anxiety/depression and catastrophizing improved in both groups, but no differences between groups were found.
Conclusions: In this fibromyalgia cohort, NAE therapy significantly improved pain and quality of life at 4 weeks, but not at 3-month follow-up, compared with the sham stimulation group. Future investigations are needed in larger populations to confirm these findings.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.)

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