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Tytuł pozycji:

Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats.

Tytuł:
Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats.
Autorzy:
Matsunaga D; Graduate School of Community & Human Services, Rikkyo University, 1-2-26 Kitano, Niiza, Saitama, 352-8558, Japan.
Nakagawa H; Graduate School of Community & Human Services, Rikkyo University, 1-2-26 Kitano, Niiza, Saitama, 352-8558, Japan; Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda, Tokyo, 102-0083, Japan.
Ishiwata T; Graduate School of Community & Human Services, Rikkyo University, 1-2-26 Kitano, Niiza, Saitama, 352-8558, Japan. Electronic address: .
Źródło:
Neuroscience letters [Neurosci Lett] 2021 Jan 23; Vol. 744, pp. 135556. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
MeSH Terms:
Anxiety/*metabolism
Brain/*metabolism
Hydroxyindoleacetic Acid/*metabolism
Physical Conditioning, Animal/*physiology
Serotonin/*metabolism
Animals ; Anxiety/psychology ; Male ; Motor Activity/physiology ; Physical Conditioning, Animal/psychology ; Rats ; Rats, Wistar
Contributed Indexing:
Keywords: Anxiety-like behavior; Forced exercise; Serotonin; Voluntary exercise; Voluntary limited exercise
Substance Nomenclature:
333DO1RDJY (Serotonin)
54-16-0 (Hydroxyindoleacetic Acid)
Entry Date(s):
Date Created: 20201229 Date Completed: 20210430 Latest Revision: 20210430
Update Code:
20240105
DOI:
10.1016/j.neulet.2020.135556
PMID:
33373674
Czasopismo naukowe
Physical exercise is beneficial to both physical and mental health, though it is unclear whether voluntary and forced exercise have the same effects. We investigated the effects of chronic forced and voluntary wheel running on brain levels of serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), and anxiety-like behavioral change in rats. Forty-eight rats were randomly assigned to standard cages (sedentary control: SC); voluntary exercise (free running on a wheel, V-EX); voluntary limited exercise (wheel available only 1 h per day, VL-EX); and forced exercise (running on a motorized wheel, F-EX). After 4 weeks, rats either underwent the open field test (OFT) or their 5-HT and 5-HIAA levels were measured in the major serotonergic neural cell bodies and projection areas. 5-HT and 5-HIAA levels in the dorsal and median raphe nuclei were increased in the V-EX, but not in the VL-EX and F-EX groups, compared with the SC group. In the paraventricular hypothalamic nucleus and caudate putamen, only 5-HT levels were increased in the V-EX group. Interestingly, in the amygdala, only 5-HIAA levels were significantly increased in the V-EX group. Conversely, we found that F-EX rats showed no significant 5-HT changes and increased anxiety-like behavior. VL-EX did not have significant beneficial effects on any of the experimental parameters. These data suggest that only unlimited voluntary exercise stimulates the serotonergic system and suppresses anxiety-like behavior.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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