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Tytuł:
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Cracking the Chloroquine Conundrum: The Application of Defective UiO-66 Metal-Organic Framework Materials to Prevent the Onset of Heart Defects-In Vivo and In Vitro.
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Autorzy:
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Jodłowski PJ; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
Kurowski G; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
Kuterasiński Ł; Polish Academy of Sciences, Jerzy Haber Institute of Catalysis and Surface Chemistry, Niezapominajek 8, 30-239 Kraków, Poland.
Sitarz M; Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
Jeleń P; Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
Jaśkowska J; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
Kołodziej A; Institute of Chemical Engineering, Polish Academy of Sciences, Bałtycka 5, 44-100 Gliwice, Poland.
Pajdak A; Strata Mechanics Research Institute, Polish Academy of Sciences, Reymonta 27, 30-059 Kraków, Poland.
Majka Z; TM LABS Sp. z o. o., Al. Beliny-Prażmowskiego 14, 31-514 Kraków, Poland.
Boguszewska-Czubara A; Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
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Źródło:
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ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jan 13; Vol. 13 (1), pp. 312-323. Date of Electronic Publication: 2020 Dec 30.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, D.C. : American Chemical Society
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MeSH Terms:
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Chloroquine/*analogs & derivatives
Heart Diseases/*drug therapy
Metal-Organic Frameworks/*pharmacology
Nanoparticles/*chemistry
Animals ; Chloroquine/adverse effects ; Chloroquine/chemistry ; Chloroquine/pharmacology ; Disease Models, Animal ; Drug Delivery Systems/adverse effects ; Drug Liberation/drug effects ; HEK293 Cells ; Heart Diseases/chemically induced ; Heart Diseases/pathology ; Humans ; Hydrochloric Acid/pharmacology ; Metal-Organic Frameworks/chemistry ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Phthalic Acids/chemistry ; Phthalic Acids/pharmacology ; Zebrafish/genetics
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Contributed Indexing:
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Keywords: SARS-CoV-2; UiO-66; chloroquine; drug delivery; metal−organic frameworks
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Substance Nomenclature:
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0 (Metal-Organic Frameworks)
0 (Organometallic Compounds)
0 (Phthalic Acids)
0 (UiO-66)
6E17K3343P (chloroquine diphosphate)
886U3H6UFF (Chloroquine)
QTT17582CB (Hydrochloric Acid)
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Entry Date(s):
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Date Created: 20201230 Date Completed: 20210128 Latest Revision: 20230829
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Update Code:
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20240105
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DOI:
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10.1021/acsami.0c21508
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PMID:
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33378177
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In this study, we present a modulated synthesis nanocrystalline defective UiO-66 metal-organic framework as a potential chloroquine diphosphate (CQ) delivery system. Increasing the concentration of hydrochloric acid during the modulated synthesis resulted in a considerable increase of pore volume, which enhanced the CQ loading in CQ@UiO-66 composites. Drug release tests for CQ@UiO-66 composites have confirmed prolonged CQ release in comparison with pure CQ. In vivo tests on a Danio reiro model organism have revealed that CQ released from CQ@UiO-66 25% showed lower toxicity and fewer cardiotoxic effects manifested by cardiac malformations and arrhythmia in comparison to analogous doses of CQ. Cytotoxicity tests proved that the CQ loaded on the defective UiO-66 cargo resulted in increased viability of cardiac cells (H9C2) as compared to incubation with pure CQ. The experimental results presented here may be a step forward in the context of reducing the cardiotoxicity CQ.
