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Tytuł:
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Changes of peripheral lymphocyte subset in patients with SARS-CoV-2 infection during the whole course of disease.
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Autorzy:
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Yu X; Department of Emergency, Renmin Hospital of Wuhan University, Wuhan, China.
Yang R; Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China.
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Źródło:
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Expert review of respiratory medicine [Expert Rev Respir Med] 2021 Apr; Vol. 15 (4), pp. 553-559. Date of Electronic Publication: 2020 Dec 31.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: London : Future Drugs, c2007-
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MeSH Terms:
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Lymphocyte Subsets*
COVID-19/*blood
Adult ; Aged ; COVID-19/diagnosis ; Disease Progression ; Female ; Humans ; Lymphocyte Count ; Male ; Middle Aged ; Prognosis ; Retrospective Studies
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Contributed Indexing:
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Keywords: Lymphocyte subsets; covid-19; immune response; sars-CoV-2
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Entry Date(s):
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Date Created: 20201231 Date Completed: 20210413 Latest Revision: 20210413
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Update Code:
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20240105
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PubMed Central ID:
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PMC7784778
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DOI:
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10.1080/17476348.2021.1866991
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PMID:
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33382362
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Background : Little is known about changes in lymphocyte subsets after SARS-CoV-2 infection. Methods : Clinical data of 580 COVID-19 patients hospitalized in Zhongnan Hospital of Wuhan University from 20 December 2019, to 8 March 2020, were retrospectively analyzed. The relation of lymphocyte subsets and severity or prognosis of disease were analyzed. Results : At 2-3 weeks after the onset of symptoms, lymphocyte subsets decreased to the lowest levels. The levels of lymphocyte subsets in asymptomatic patients were close to healthy persons, except for CD8 + T lymphocyte cells. The levels of lymphocyte subsets in patients with severe illness were lower than that in patients with mild-to-moderate illness ( P < 0.01). Similarly, among patients with severe illness, lower levels of lymphocyte subsets were found in dead patients compared to survivors ( P < 0.001). Moreover, by comparing the results of the same patients at different stages of the disease, we found levels of lymphocyte subsets were lower in the acute phase compared to that in convalescent-phase ( P < 0.001). However, the levels of lymphocyte subsets in patients who had SARS-CoV-2 viral load >5000 copies/ml and 500-5000 copies/ml were at similar levels. Conclusions : Lymphocyte subsets are a good biomarker to assess the severity and prognosis of the disease at 2-3 weeks after the onset of symptoms.