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Tytuł:
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White matter microstructure across brain-based biotypes for psychosis - findings from the bipolar-schizophrenia network for intermediate phenotypes.
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Autorzy:
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Kelly S; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address: .
Guimond S; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States; Department of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada.
Pasternak O; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Lutz O; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
Lizano P; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
Cetin-Karayumak S; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Sweeney JA; Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45221, United States.
Pearlson G; Department of Psychiatry, Yale University, New Haven, CT 06520, United States.
Clementz BA; Department of Psychology, University of Georgia, Athens, GA 30602, United States.
McDowell JE; Department of Psychology, University of Georgia, Athens, GA 30602, United States.
Tamminga CA; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, United States.
Shenton ME; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Keshavan MS; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
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Źródło:
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Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2021 Feb 28; Vol. 308, pp. 111234. Date of Electronic Publication: 2020 Dec 16.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier
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MeSH Terms:
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Bipolar Disorder*/diagnostic imaging
Psychotic Disorders*/diagnostic imaging
Schizophrenia*/diagnostic imaging
White Matter*/diagnostic imaging
Brain/diagnostic imaging ; Diffusion Tensor Imaging ; Humans ; Phenotype
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Entry Date(s):
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Date Created: 20210101 Date Completed: 20210520 Latest Revision: 20210520
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Update Code:
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20240105
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DOI:
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10.1016/j.pscychresns.2020.111234
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PMID:
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33385763
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The B-SNIP consortium identified three brain-based Biotypes across the psychosis spectrum, independent of clinical phenomenology. To externally validate the Biotype model, we used free-water fractional volume (FW) and free-water corrected fractional anisotropy (FA T ) to compare white matter differences across Biotypes and clinical diagnoses. Diffusion tensor imaging data from 167 individuals were included: 41 healthy controls, 55 schizophrenia probands, 47 schizoaffective disorder probands, and 24 probands with psychotic bipolar disorder. Compared to healthy controls, FAt reductions were observed in the body of corpus callosum (BCC) for schizoaffective disorder (d = 0.91) and schizophrenia (d = 0.64). Grouping by Biotype, Biotype 1 showed FAt reductions in the CC and fornix, with largest effect in the BCC (d = 0.87). Biotype 2 showed significant FAt reductions in the BCC (d = 0.90). Schizoaffective disorder individuals had elevated FW in the CC, fornix and anterior corona radiata (ACR), with largest effect in the BCC (d = 0.79). Biotype 2 showed elevated FW in the CC, fornix and ACR, with largest effect in the BCC (d = 0.94). While significant diagnosis comparisons were observed, overall greater discrimination from healthy controls was observed for lower FAt in Biotype 1 and elevated FW in Biotype 2. However, between-group differences were modest, with one region (cerebral peduncle) showing a between-Biotype effect. No between-group effects were observed for diagnosis groupings.
(Copyright © 2020. Published by Elsevier B.V.)
