Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

HLA-E typing of more than 2.5 million potential hematopoietic stem cell donors: Methods and population-specific allele frequencies.

Tytuł :
HLA-E typing of more than 2.5 million potential hematopoietic stem cell donors: Methods and population-specific allele frequencies.
Autorzy :
Sauter J; DKMS, Tübingen, Germany.
Putke K; DKMS Life Science Lab, Dresden, Germany.
Schefzyk D; DKMS, Tübingen, Germany.
Pruschke J; DKMS, Tübingen, Germany.
Solloch UV; DKMS, Tübingen, Germany.
Bernas SN; DKMS, Tübingen, Germany.
Massalski C; DKMS Life Science Lab, Dresden, Germany.
Daniel K; DKMS Life Science Lab, Dresden, Germany.
Klussmeier A; DKMS Life Science Lab, Dresden, Germany.
Hofmann JA; DKMS, Tübingen, Germany.
Lange V; DKMS Life Science Lab, Dresden, Germany.
Schmidt AH; DKMS, Tübingen, Germany; DKMS Life Science Lab, Dresden, Germany. Electronic address: .
Pokaż więcej
Źródło :
Human immunology [Hum Immunol] 2021 Jul; Vol. 82 (7), pp. 541-547. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: [New York] Elsevier/North-Holland.
Contributed Indexing :
Keywords: Allele frequency distributions; Donor registry; HLA-E; Population genetics; Unrelated haematopoietic stem cell transplantation
Entry Date(s) :
Date Created: 20210102 Latest Revision: 20210621
Update Code :
20210914
DOI :
10.1016/j.humimm.2020.12.008
PMID :
33386168
Czasopismo naukowe
We developed a cost-efficient workflow for genotyping HLA-E by NGS and applied it for genotyping more than 2.5 million potential stem cell donors. The data obtained were used to determine HLA-E allele frequency distributions for 104 populations. Our results confirm the known dominance of the alleles E*01:01 and E*01:03, which have a combined frequency of more than 0.99 in 97 of the 104 populations. E*01:01 is more frequent in Africa and the western part of South America, E*01:03 in Southeast and East Asia. E*01:03 shows a pronounced regional substructure at the high-resolution level with E*01:03:01G being particularly common in a large connected region extending from Turkey to China, E*01:03:02G in Northwestern Europe and E*01:03:03 in Central and Eastern Europe as well as Central Asia. The presented results are relevant both as a basis for further population genetics studies and for optimizing stem cell donor searches.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies