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Tytuł:
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Effect of silver diammine fluoride and glass ionomer on remineralisation of natural dentine caries.
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Autorzy:
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Panahpour Eslami N; University of Washington School of Dentistry, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Chan DCN; Department of Restorative Dentistry, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Sadr A; Department of Restorative Dentistry, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA. Electronic address: .
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Źródło:
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Journal of dentistry [J Dent] 2021 Mar; Vol. 106, pp. 103578. Date of Electronic Publication: 2020 Dec 31.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Kidlington : Elsevier
Original Publication: Bristol, Eng., Wright.
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MeSH Terms:
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Dental Caries*/diagnostic imaging
Dental Caries*/drug therapy
Fluorides*
Acrylic Resins ; Ammonia ; Dental Caries Susceptibility ; Dentin/diagnostic imaging ; Fluorides, Topical ; Glass Ionomer Cements ; Humans ; Quaternary Ammonium Compounds ; Silicon Dioxide ; Silver Compounds
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Contributed Indexing:
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Keywords: Dentine remineralisation; Glass ionomer cement; MicroCT; Natural caries; Silver diammine fluoride
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Substance Nomenclature:
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0 (Acrylic Resins)
0 (Fluorides, Topical)
0 (Glass Ionomer Cements)
0 (Quaternary Ammonium Compounds)
0 (Silver Compounds)
0 (glass ionomer)
16972-61-5 (silver diammine)
7631-86-9 (Silicon Dioxide)
7664-41-7 (Ammonia)
Q80VPU408O (Fluorides)
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Entry Date(s):
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Date Created: 20210103 Date Completed: 20210423 Latest Revision: 20210423
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Update Code:
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20240105
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DOI:
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10.1016/j.jdent.2020.103578
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PMID:
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33388389
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Objectives: Silver diammine fluoride (SDF) is a caries-arresting agent for dentine lesions. This study investigated the effect of application frequency of SDF when used with glass ionomer cement (GI) for remineralising carious dentine.
Methods: Freshly extracted human posterior teeth with advanced caries were used. After superficial removal of infected dentine, single (G3), double (G4), triple (G5) applications of SDF (Advantage Arrest SDF 38 %) followed by a layer of GI (GC Fuji IX GP) were compared to no treatment (negative control-G2), and GI only (G1). All teeth were stored in artificial saliva between treatments and for 2-weeks after final treatment. Micro-computed X-ray tomography (NSI) scans were obtained at each stage and analysed to plot mineral density-depth profile, lesion depth (LD) and mineral loss (ΔZ). Data was statistically analysed at a significance level of 0.05.
Results: Mean LD values were 837 μm, 735 μm, 841 μm, 1008 μm, 707 μm at baseline and 785 μm, 727 μm, 712 μm, 855 μm, 639 μm after treatment for groups G1 to G5, respectively. Mean ΔZ values were 6327 vol%μm, 5995 vol%μm, 10014 vol%μm, 7192 vol%μm, 5649 vol%μm at baseline and 3686 vol%μm, 5126 vol%μm, 5539 vol%μm, 2327 vol%μm, 3218 vol%μm after treatment for groups G1 to G5, respectively. Paired t-test showed that LD and ΔZ changed significantly within all groups from baseline to treatment weeks following storage (p < 0.05) except LD in the control (p > 0.05). ANCOVA showed significant difference among groups in net lesion depth recovery and net mineral gain (p < 0.05), and G3 and G4 showed the highest mineral gains.
Conclusion: One or two applications of SDF prior to placement of GI, were effective in remineralising advanced dentine lesions, while additional applications, when combined with GI, did not demonstrate additional benefit in this study.
Clinical Significance: This short-term laboratory research study showed that one or two applications of SDF followed by GI coverage could remineralise advanced dentine caries in the presence of artificial saliva. This procedure carries potential in the treatment of difficult lesions where conventional restorations would require significant tooth structure removal through traumatic procedures.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
