Ecthyma gangrenosum: The critical role of biofilms and other mechanisms of antibiotic resistance and implications for management.

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Tytuł:: Ecthyma gangrenosum: The critical role of biofilms and other mechanisms of antibiotic resistance and implications for management.
Autorzy:: Russomanno K; Department of Dermatology, Medstar Georgetown University Hospital/Medstar Washington Hospital Center, Washington, DC, USA.; Department of Internal Medicine, Medstar Washington Hospital Center, Washington, DC, USA.
Cardis M; Department of Dermatology, Medstar Georgetown University Hospital/Medstar Washington Hospital Center, Washington, DC, USA.
Kirkorian AY; Division of Dermatology, Children's National Hospital, Washington, DC, USA.; George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Źródło:: Pediatric dermatology [Pediatr Dermatol] 2021 Mar; Vol. 38 (2), pp. 458-460. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji:: Case Reports
Język:: English
Imprint Name(s):: Publication: <2010->: Hoboken, NJ : Wiley
Original Publication: [Boston, MA] : Blackwell Scientific Publications, [1983-
MeSH Terms:: Ecthyma*/diagnosis
Ecthyma*/drug therapy
Pseudomonas Infections*/diagnosis
Pseudomonas Infections*/drug therapy
Biofilms ; Drug Resistance, Microbial ; Humans ; Pseudomonas aeruginosa
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Jiang Y, Al-Hatmi AM, Xiang Y, et al. The concept of ecthyma gangrenosum illustrated by a Fusarium oxysporum infection in an immunocompetent individual. Mycopathologia. 2016;181(9-10):759-763.
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Weiel JJ, Zhang CZ, Smith JA, et al. Clinicopathologic aspects of ecthyma gangrenosum in pediatric patients: a case series and review of the literature. J Clin Anat Pathol. 2013;1:1-5.
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Contributed Indexing:: Keywords: Pseudomonas aeruginosa; antibiotic resistance; ecthyma; ecthyma gangrenosum; pseudomonas infections
Entry Date(s):: Date Created: 20210103 Date Completed: 20210514 Latest Revision: 20210514
Update Code:: 20240105
DOI:: 10.1111/pde.14496
PMID:: 33389781
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Ecthyma gangrenosum is a rare cutaneous infection that occurs classically in immunocompromised patients with Pseudomonas aeruginosa bacteremia and is associated with a high mortality rate. Causative pathogens may exhibit various antibiotic evasion mechanisms, and thus, treatment may be challenging. We present a case of ecthyma gangrenosum in association with an implantable port in which cultures confirmed ten unique strains of Pseudomonas aeruginosa, highlighting the ability of this pathogen to form biofilms, rapidly mutate and ultimately evade antibiotic therapy. Dermatologists play a key role in the prompt diagnosis of this life-threatening condition, and a thorough understanding of pathogenic mechanisms is critical in selecting an efficacious treatment regimen.
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