Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study.

Szczegóły
Abstrakt

Tytuł:: Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study.
Autorzy:: Kodama K; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yahata H; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. .
Okugawa K; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Tomonobe H; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yasutake N; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yoshida S; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yagi H; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yasunaga M; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Ohgami T; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Onoyama I; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Asanoma K; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Hori E; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Shimokawa M; Department of Biostatistics, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Kato K; Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Źródło:: International journal of clinical oncology [Int J Clin Oncol] 2021 Apr; Vol. 26 (4), pp. 770-776. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 1998- : Tokyo : Springer-Verlag Tokyo
Original Publication: Tokyo : Published for the Japan Society of Clinical Oncology by Churchill Livingstone, c1996-
MeSH Terms:: Laser Therapy*
Papillomavirus Infections*
Uterine Cervical Neoplasms*/surgery
Uterine Cervical Dysplasia*/surgery
Adolescent ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Papillomaviridae ; Prognosis ; Retrospective Studies ; Risk Factors ; Young Adult
References:: Parkin DM, Bray F, Ferlay J et al (2002) (2005) Global cancer statistics. CA Cancer J Clin 55(2):74–108. https://doi.org/10.3322/canjclin.55.2.74. (PMID: 10.3322/canjclin.55.2.74)
International Agency for Research on Cancer Multicenter Cervical Cancer Study G, Munoz N, Bosch FX, de Sanjose S et al (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348(6):518–527. https://doi.org/10.1056/NEJMoa021641. (PMID: 10.1056/NEJMoa021641)
Brianti P, De Flammineis E, Mercuri SR (2017) Review of HPV-related diseases and cancers. New Microbiol 40(2):80–85. (PMID: 28368072)
Ostör AG (1993) Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 12(2):186–192. (PMID: 10.1097/00004347-199304000-00018)
Ginsburg O, Bray F, Coleman MP et al (2017) The global burden of women’s cancers: a grand challenge in global health. The Lancet 389(10071):847–860. https://doi.org/10.1016/s0140-6736(16)31392-7. (PMID: 10.1016/s0140-6736(16)31392-7)
Sawaya GF, Smith-McCune K, Kuppermann M (2019) Cervical cancer screening: more choices in 2019. JAMA 321(20):2018–2019. https://doi.org/10.1001/jama.2019.4595. (PMID: 10.1001/jama.2019.4595311358346656358)
Kocken M, Helmerhorst TJM, Berkhof J et al (2011) Risk of recurrent high-grade cervical intraepithelial neoplasia after successful treatment: a long-term multi-cohort study. Lancet Oncol 12(5):441–450. https://doi.org/10.1016/s1470-2045(11)70078-x. (PMID: 10.1016/s1470-2045(11)70078-x21530398)
Sadler L, Saftlas A, Wang W et al (2004) Treatment for cervical intraepithelial neoplasia and risk of preterm delivery. JAMA 291(17):2100–2106. https://doi.org/10.1001/jama.291.17.2100. (PMID: 10.1001/jama.291.17.210015126438)
Kyrgiou M, Koliopoulos G, Martin-Hirsch P et al (2006) Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis. Lancet 367(9509):489–498. https://doi.org/10.1016/s0140-6736(06)68181-6. (PMID: 10.1016/s0140-6736(06)68181-616473126)
Mathevet P, Chemali E, Roy M et al (2003) Long-term outcome of a randomized study comparing three techniques of conization: cold knife, laser, and LEEP. Eur J Obstet Gynecol Reprod Biol 106(2):214–218. https://doi.org/10.1016/s0301-2115(02)00245-2. (PMID: 10.1016/s0301-2115(02)00245-212551795)
Anderson MC, Hartley RB (1979) Cervical crypt involvement by intraepithelial neoplasia. Obstet Gynecol Surv 34(11):852–853. https://doi.org/10.1097/00006254-197911000-00031. (PMID: 10.1097/00006254-197911000-00031523037)
Jordan JA, Woodman CB, Mylotte MJ et al (1985) The treatment of cervical intraepithelial neoplasia by laser vaporization. Br J Obstet Gynaecol 92(4):394–398. https://doi.org/10.1111/j.1471-0528.1985.tb01114.x. (PMID: 10.1111/j.1471-0528.1985.tb01114.x3986168)
Partington CK, Turner MJ, Soutter WP et al (1989) Laser vaporization versus laser excision conization in the treatment of cervical intraepithelial neoplasia. Obstet Gynecol 73:775–779. (PMID: 2649822)
Alvarez RD, Helm CW, Edwards RP et al (1994) Prospective randomized trial of LLETZ versus laser ablation in patients with cervical intraepithelial neoplasia. Gynecol Oncol 52(2):175–179. https://doi.org/10.1006/gyno.1994.1027. (PMID: 10.1006/gyno.1994.10278314135)
Dey P, Gibbs A, Arnold DF et al (2002) Loop diathermy excision compared with cervical laser vaporisation for the treatment of intraepithelial neoplasia: a randomised controlled trial. BJOG 109(4):381–385. https://doi.org/10.1111/j.1471-0528.2002.01277.x. (PMID: 10.1111/j.1471-0528.2002.01277.x12013158)
Mariya T, Nishikawa A, Sogawa K et al (2016) Virological and cytological clearance in laser vaporization and conization for cervical intra-epithelial neoplasia grade 3. J Obstet Gynaecol Res 42(12):1808–1813. https://doi.org/10.1111/jog.13113. (PMID: 10.1111/jog.1311327526956)
Inaba K, Nagasaka K, Kawana K et al (2014) High-risk human papillomavirus correlates with recurrence after laser ablation for treatment of patients with cervical intraepithelial neoplasia 3: a long-term follow-up retrospective study. J Obstet Gynaecol Res 40(2):554–560. https://doi.org/10.1111/jog.12196. (PMID: 10.1111/jog.1219624118526)
Stentella P, Pace S, Villani C et al (1995) Cervical intraepithelial neoplasia: carbon dioxide laser vaporization and conization. Our Exp Eur J Gynaecol Oncol 16(4):282–289.
Soutter WP, de Barros LA, Fletcher A et al (1997) Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia. Lancet 349(9057):978–980. https://doi.org/10.1016/s0140-6736(96)08295-5. (PMID: 10.1016/s0140-6736(96)08295-59100623)
Soutter WP, Sasieni P, Panoskaltsis T (2006) Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia. Int J Cancer 118(8):2048–2055. https://doi.org/10.1002/ijc.21604. (PMID: 10.1002/ijc.2160416284947)
Chew GK, Jandial L, Paraskevaidis E et al (1999) Pattern of CIN recurrence following laser ablation treatment: long-term follow-up. Int J Gynecol Cancer 9(6):487–490. https://doi.org/10.1046/j.1525-1438.1999.99066.x. (PMID: 10.1046/j.1525-1438.1999.99066.x11240816)
Persad VL, Pierotic MA, Guijon FB (2001) Management of cervical neoplasia: a 13-year experience with cryotherapy and laser. J Low Genit Tract Dis 5(4):199–203. https://doi.org/10.1046/j.1526-0976.2001.54002.x. (PMID: 10.1046/j.1526-0976.2001.54002.x17050975)
Chen JY, Wang ZL, Wang ZY et al (2018) The risk factors of residual lesions and recurrence of the high-grade cervical intraepithelial lesions (HSIL) patients with positive-margin after conization. Medicine (Baltimore) 97(41):e12792. https://doi.org/10.1097/MD.0000000000012792. (PMID: 10.1097/MD.0000000000012792)
Melnikow J, McGahan C, Sawaya GF et al (2009) Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort Study. J Natl Cancer Inst 101(10):721–728. https://doi.org/10.1093/jnci/djp089. (PMID: 10.1093/jnci/djp089194360262684554)
Bogani G, Cromi A, Serati M et al (2015) Laparoscopic and vaginal approaches to hysterectomy in the obese. Eur J Obstet Gynecol Reprod Biol 189:85–90. https://doi.org/10.1016/j.ejogrb.2015.02.035. (PMID: 10.1016/j.ejogrb.2015.02.03525898369)
Byun JM, Jeong DH, Kim YN et al (2018) Persistent HPV-16 infection leads to recurrence of high-grade cervical intraepithelial neoplasia. Medicine (Baltimore) 97(51):e13606. https://doi.org/10.1097/MD.0000000000013606. (PMID: 10.1097/MD.0000000000013606)
Grant Information:: JP19K09804 Japan Society for the Promotion of Science London
Contributed Indexing:: Keywords: Cervical intraepithelial neoplasia; Laser vaporization; Recurrence-free interval
Entry Date(s):: Date Created: 20210104 Date Completed: 20210323 Latest Revision: 20221207
Update Code:: 20240105
DOI:: 10.1007/s10147-020-01848-x
PMID:: 33394202
: Czasopismo naukowe

Full Text Finder

Background: Cervical intraepithelial neoplasia (CIN) is a precancerous lesion that may progress to invasive cervical cancer without intervention. We aim to examine the prognostic outcomes and risk factors for recurrence after laser vaporization for CIN 3, CIN 2 with high-risk human papillomavirus (HPV) infection, and CIN 1 persisting for more than 2 years.
Methods: Between 2008 and 2016, a total of 1070 patients underwent cervical laser vaporization using a carbon dioxide laser. We performed a retrospective review of their medical records to assess their clinical characteristics, pathologic factors, and prognostic outcomes.
Results: The mean patient age was 34 years (range 18-64 years). The preoperative diagnosis was CIN 1 in 27 patients, CIN 2 in 485 patients, and CIN 3 in 558 patients. Over a median follow-up period of 15 months, the 2-year recurrence rate was 18.9%, and the 5-year recurrence rate was 46.5%. The 2-year retreatment rate was 12.6%, and the 5-year retreatment rate was 30.5%. We diagnosed 9 patients with invasive cancer after treatment; all patients underwent combined multidisciplinary treatment, and there were no deaths during follow-up. The recurrence-free interval was correlated with patient age (hazard ratio [HR], 1.028; 95% CI 1.005-1.051; P = 0.0167), body mass index (HR, 1.052; 95% CI 1.008-1.098; P = 0.0191), and glandular involvement (HR, 1.962; 95% CI 1.353-2.846; P = 0.0004).
Conclusions: Cervical laser vaporization is effective and useful for patients with CIN who wish to preserve fertility. However, patients with glandular involvement, older age, and higher body weight require close follow-up for recurrence.

Informacja