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Tytuł:
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Estimation of toluene exposure in air from BMA (S-benzylmercapturic acid) urinary measures using a reverse dosimetry approach based on physiologically pharmacokinetic modeling.
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Autorzy:
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Tohon H; Department of Environmental and Occupational Health, ESPUM, CReSP, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montreal, Qc, H3C 3J7, Canada.
Valcke M; Department of Environmental and Occupational Health, ESPUM, CReSP, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montreal, Qc, H3C 3J7, Canada; Direction de la santé environnementale et de la toxicologie, Institut national de santé publique du Québec, Montréal, Quebec, Canada.
Aranda-Rodriguez R; Exposure and Biomonitoring Division, Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada.
Nong A; Exposure and Biomonitoring Division, Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada.
Haddad S; Department of Environmental and Occupational Health, ESPUM, CReSP, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montreal, Qc, H3C 3J7, Canada. Electronic address: .
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Źródło:
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Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Mar; Vol. 120, pp. 104860. Date of Electronic Publication: 2021 Jan 03.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
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MeSH Terms:
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Models, Biological*
Acetylcysteine/*analogs & derivatives
Air Pollutants/*toxicity
Environmental Biomarkers/*drug effects
Environmental Monitoring/*methods
Toluene/*toxicity
Acetylcysteine/urine ; Adult ; Environmental Biomarkers/physiology ; Humans ; Monte Carlo Method
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Contributed Indexing:
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Keywords: And exposure assessment; Biomonitoring; PBPK modeling; Reverse dosimetry; Toluene; Uncertainty; Urinary BMA
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Substance Nomenclature:
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0 (Air Pollutants)
0 (Environmental Biomarkers)
3FPU23BG52 (Toluene)
WYQ7N0BPYC (Acetylcysteine)
X3H719RFPT (S-benzyl-N-acetyl-L-cysteine)
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Entry Date(s):
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Date Created: 20210106 Date Completed: 20210924 Latest Revision: 20210924
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Update Code:
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20240105
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DOI:
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10.1016/j.yrtph.2020.104860
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PMID:
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33406392
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This study aimed to use a reverse dosimetry PBPK modeling approach to estimate toluene atmospheric exposure from urinary measurements of S-benzylmercapturic acid (BMA) in a small group of individuals and to evaluate the uncertainty associated to urinary spot-sampling compared to 24-h collected urine samples. Each exposure assessment technique was developed namely to estimate toluene air exposure from BMA measurements in 24-h urine samples (24-h-BMA) and from distributions of daily urinary BMA spot measurements (DUBSM). Model physiological parameters were described based upon age, weight, size and sex. Monte Carlo simulations with the PBPK model allowed converting DUBSM distribution (and 24-h-BMA) into toluene air levels. For the approach relying on DUBSM distribution, the ratio between the 95% probability of predicted toluene concentration and its 50% probability in each individual varied between 1.2 and 1.4, while that based on 24-h-BMA varied between 1.0 and 1.1. This suggests more variability in estimated exposure from spot measurements. Thus, estimating toluene exposure based on DUBSM distribution generated about 20% more uncertainty. Toluene levels estimated (0.0078-0.0138 ppm) are well below Health Canada's maximum chronic air guidelines. PBPK modeling and reverse dosimetry may be combined to interpret urinary metabolites data of VOCs and assess related uncertainties.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
