RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer.

Tytuł:: RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer.
Autorzy:: Luzón-Toro B; Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases CIBERER, Seville, Spain.
Villalba-Benito L; Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases CIBERER, Seville, Spain.
Fernández RM; Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases CIBERER, Seville, Spain.
Torroglosa A; Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases CIBERER, Seville, Spain.
Antiñolo G; Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases CIBERER, Seville, Spain.
Borrego S; Department of Maternofetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC, University of Seville, Seville, Spain. .; Centre for Biomedical Network Research on Rare Diseases CIBERER, Seville, Spain. .
Źródło:: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Jan 06; Vol. 16 (1), pp. 4. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [London] : BioMed Central, 2006-
MeSH Terms:: Carcinoma, Medullary*
Multiple Endocrine Neoplasia Type 2a*
RNA, Long Noncoding*/genetics
Thyroid Neoplasms*/genetics
Carcinoma, Neuroendocrine ; Humans ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-ret/genetics
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Contributed Indexing:: Keywords: FTX; IPW; MEN2; MTC; RMRP; RMST; lncRNA
Substance Nomenclature:: 0 (MAS1 protein, human)
0 (Proto-Oncogene Mas)
0 (RNA, Long Noncoding)
EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
SCR Disease Name:: Thyroid cancer, medullary
Entry Date(s):: Date Created: 20210107 Date Completed: 20210618 Latest Revision: 20231110
Update Code:: 20240105
PubMed Central ID:: PMC7789680
DOI:: 10.1186/s13023-020-01665-5
PMID:: 33407723
: Raport

Pełny tekst

The relevant role of long non-coding RNAs (lncRNAs) in cancer is currently a matter of increasing interest. Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor (2-5% of all thyroid cancer) derived from the parafollicular C-cells which secrete calcitonin. About 75% of all medullary thyroid cancers are believed to be sporadic medullary thyroid cancer (sMTC), whereas the remaining 25% correspond to inherited cancer syndromes known as Multiple Endocrine Neoplasia type 2 (MEN2). MEN2 syndrome, with autosomal dominant inheritance is caused by germline gain of function mutations in RET proto-oncogene. To date no lncRNA has been associated to MEN2 syndrome and only two articles have been published relating long non-coding RNA (lncRNA) to MTC: the first one linked MALAT1 with sMTC and, in the other, our group determined some new lncRNAs in a small group of sMTC cases in fresh tissue (RMST, FTX, IPW, PRNCR1, ADAMTS9-AS2 and RMRP). The aim of the current study is to validate such novel lncRNAs previously described by our group by using a larger cohort of patients, in order to discern their potential role in the disease. Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. The preliminary results reinforce the potential role of RMST, FTX, IPW and RMRP in the pathogenesis of MTC.

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