Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Protection studies of an excretory-secretory protein HcABHD against Haemonchus contortus infection.

Tytuł :
Protection studies of an excretory-secretory protein HcABHD against Haemonchus contortus infection.
Autorzy :
Lu M; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Tian X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Zhang Y; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Wang W; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Tian AL; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, P. R. China.
Aimulajiang K; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Liu L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Li C; Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD, 20705, USA.
Yan R; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Xu L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Song X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China.
Li X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, P. R. China. .
Pokaż więcej
Źródło :
Veterinary research [Vet Res] 2021 Jan 06; Vol. 52 (1), pp. 3. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
Język :
English
Imprint Name(s) :
Publication: 2011- : London : BioMed Central
Original Publication: Paris : Editions Scientifiques Elsevier ; INRA, c1993-
MeSH Terms :
Goat Diseases/*parasitology
Haemonchiasis/*veterinary
Haemonchus/*immunology
Helminth Proteins/*therapeutic use
Vaccines/*therapeutic use
Animals ; Antigens, Helminth/therapeutic use ; Enzyme-Linked Immunosorbent Assay ; Female ; Goat Diseases/prevention & control ; Goats ; Haemonchiasis/prevention & control ; Male ; Parasite Egg Count/veterinary ; Vaccines, Synthetic/therapeutic use
References :
J Immunol. 1993 Nov 15;151(10):5450-60. (PMID: 7693812)
Vet Res. 2019 Jun 4;50(1):42. (PMID: 31164173)
Trends Parasitol. 2017 Sep;33(9):678-693. (PMID: 28566191)
Parasite Immunol. 2010 Jun;32(6):414-9. (PMID: 20500672)
Vet Res. 2020 May 13;51(1):65. (PMID: 32404195)
Front Immunol. 2017 Oct 30;8:1437. (PMID: 29163510)
Vaccine. 2013 Aug 20;31(37):4017-23. (PMID: 23707168)
Adv Parasitol. 2016;93:95-143. (PMID: 27238004)
Int J Parasitol. 2011 Apr;41(5):487-93. (PMID: 21172352)
Vet Res. 2010 Jul-Aug;41(4):37. (PMID: 20167198)
Parasite Immunol. 1997 Oct;19(10):447-53. (PMID: 9372512)
Adv Parasitol. 2016;93:353-96. (PMID: 27238008)
Parasite Immunol. 2002 Apr;24(4):189-201. (PMID: 12010484)
Vet Parasitol. 2015 Jun 30;211(1-2):54-9. (PMID: 25997645)
Mucosal Immunol. 2018 Mar;11(2):304-315. (PMID: 29297502)
Int J Parasitol. 2010 Feb;40(2):215-22. (PMID: 19695255)
Exp Parasitol. 2015 Jul;154:98-107. (PMID: 25913090)
Vet Parasitol. 2015 Jun 30;211(1-2):102-5. (PMID: 25986324)
PLoS One. 2013 Oct 21;8(10):e78357. (PMID: 24205209)
Parasit Vectors. 2017 Jun 26;10(1):311. (PMID: 28651566)
Int J Parasitol. 2013 Mar;43(3-4):301-10. (PMID: 23291463)
Int J Parasitol. 2016 Nov;46(12):755-769. (PMID: 27620133)
Vet Parasitol. 2008 May 31;153(3-4):302-12. (PMID: 18337013)
Vet Res. 2006 Jul-Aug;37(4):607-22. (PMID: 16701066)
Parasitol Today. 1999 Mar;15(3):116-22. (PMID: 10322325)
Adv Parasitol. 2016;93:181-238. (PMID: 27238006)
Int J Parasitol. 2007 Aug;37(10):1117-25. (PMID: 17451718)
Drug Saf. 2015 Nov;38(11):1059-74. (PMID: 26446142)
Vet Parasitol. 1997 Nov;72(3-4):507-16; discussion 516-23. (PMID: 9460215)
Parasite Immunol. 2016 Jun;38(6):333-9. (PMID: 27059919)
Mol Biochem Parasitol. 2014 Jul;195(2):130-6. (PMID: 24704440)
Vet Parasitol. 2016 Apr 15;220:93-107. (PMID: 26995728)
Vet Parasitol. 2017 Aug 30;243:100-104. (PMID: 28807275)
Exp Parasitol. 2007 Oct;117(2):208-13. (PMID: 17482594)
Parasit Vectors. 2014 Jul 23;7:342. (PMID: 25056558)
Parasite Immunol. 2019 Jul;41(7):e12625. (PMID: 30883834)
Nat Med. 2012 Jan 15;18(2):260-6. (PMID: 22245779)
Parasite Immunol. 2011 Jul;33(7):377-81. (PMID: 21535018)
Vet Res. 2009 Jul-Aug;40(4):41. (PMID: 19401141)
Parasite Immunol. 2002 Jan;24(1):39-46. (PMID: 11856445)
Adv Parasitol. 2016;93:397-428. (PMID: 27238009)
Front Immunol. 2020 Jun 30;11:1388. (PMID: 32695121)
Vet Parasitol. 2019 Mar;267:47-53. (PMID: 30878085)
Immunity. 2017 Dec 19;47(6):1024-1036. (PMID: 29262347)
Parasite Immunol. 2006 Mar;28(3):107-15. (PMID: 16441509)
Vet Immunol Immunopathol. 2000 Jun 30;75(1-2):109-20. (PMID: 10889303)
Vet Parasitol. 2016 Jan 15;215:72-7. (PMID: 26790740)
Pathogens. 2016 Sep 14;5(3):. (PMID: 27649248)
Semin Immunopathol. 2016 Sep;38(5):581-603. (PMID: 27225312)
Vaccine. 2004 Jan 26;22(5-6):618-28. (PMID: 14741153)
Parasite Immunol. 2003 Jun;25(6):313-23. (PMID: 14507329)
Vaccine. 2012 Nov 26;30(50):7199-204. (PMID: 23107597)
Parasit Vectors. 2019 Mar 14;12(1):105. (PMID: 30871600)
Pathogens. 2020 Jan 06;9(1):. (PMID: 31935869)
Vet Rec. 1997 Oct 4;141(14):357-60. (PMID: 9351182)
Front Immunol. 2018 Jul 16;9:1627. (PMID: 30061894)
Vet Parasitol. 2020 Mar;279:109045. (PMID: 32045836)
Parasite Immunol. 2007 Jun;29(6):319-26. (PMID: 17518950)
Grant Information :
2017YFD0501200 National Key Research and Development Program of China; BZ2019013 Policy Guidance Project of Jiangsu Province for International Scientific and Technological Cooperation; 2015CB150300 National Key Basic Research Program (973 Program)
Contributed Indexing :
Keywords: H. contortus; excretory–secretory protein; goats; immunization; Α/β-hydrolase
Substance Nomenclature :
0 (Antigens, Helminth)
0 (Helminth Proteins)
0 (Vaccines)
0 (Vaccines, Synthetic)
Entry Date(s) :
Date Created: 20210107 Date Completed: 20210121 Latest Revision: 20210121
Update Code :
20210210
PubMed Central ID :
PMC7786147
DOI :
10.1186/s13567-020-00871-0
PMID :
33407892
Czasopismo naukowe
Unlike the successful immunization of native H. contortus antigens that contributed to the realization of the first commercial vaccine Barbervax, not many studies revealed the encouraging protective efficacies of recombinant H. contortus antigens in laboratory trials or under field conditions. In our preliminary study, H. contortus α/β-hydrolase domain protein (HcABHD) was demonstrated to be an immunomodulatory excretory-secretory (ES) protein that interacts with goat T cells. We herein evaluated the protective capacities of two HcABHD preparations, recombinant HcABHD (rHcABHD) antigen and anti-rHcABHD IgG, against H. contortus challenge via active and passive immunization trials, respectively. Parasitological parameter, antibody responses, hematological pathology and cytokine profiling in unchallenged and challenged goats were monitored and determined throughout both trials. Subcutaneous administration of rHcABHD with Freund adjuvants elicited protective immune responses in challenged goats, diminishing cumulative fecal egg counts (FEC) and total worm burden by 54.0% and 74.2%, respectively, whereas passive immunization with anti-rHcABHD IgG conferred substantial protection to challenged goats by generating a 51.5% reduction of cumulative FEC and a 73.8% reduction of total worm burden. Additionally, comparable changes of mucosal IgA levels, circulating IgG levels, hemoglobin levels, and serum interleukin (IL)-4 and IL-17A levels were observed in rHcABHD protein/anti-rHcABHD IgG immunized goats in both trials. Taken together, the recombinant version of HcABHD might have further application under field conditions in protecting goats against H. contortus infection, and the integrated immunological pipeline of ES antigen identification, screening and characterization may provide new clues for further development of recombinant subunit vaccines to control H. contortus.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies