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Tytuł pozycji:

Sampling challenges in diagnosis of chronic bacterial infections.

Tytuł:
Sampling challenges in diagnosis of chronic bacterial infections.
Autorzy:
Jakobsen TH; Costerton Biofilm Center, Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Xu Y; Bio- and Environmental Technology, Danish Technological Institute, Taastrup, Denmark.; Center for Microbial Communities, Department of Chemistry and Biosciences, Aalborg University, Aalborg, Denmark.
Bay L; Costerton Biofilm Center, Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Schønheyder HC; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.
Jakobsen T; Department of Orthopaedics, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Bjarnsholt T; Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Costerton Biofilm Center, Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Thomsen TR; Bio- and Environmental Technology, Danish Technological Institute, Taastrup, Denmark.; Center for Microbial Communities, Department of Chemistry and Biosciences, Aalborg University, Aalborg, Denmark.
Źródło:
Journal of medical microbiology [J Med Microbiol] 2021 Mar; Vol. 70 (3). Date of Electronic Publication: 2021 Jan 07.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: 2015- : London : Microbiology Society
Original Publication: 1968-1995: Edinburgh, Livingstone.
MeSH Terms:
Chronic Disease*
Specimen Handling*
Bacteria/*isolation & purification
Bacterial Infections/*diagnosis
Biofilms ; Humans ; Liquid Biopsy ; Prosthesis-Related Infections/diagnosis
Contributed Indexing:
Keywords: Infections; bacterial aggregates; biofilms; clinical sampling; diagnostics; specimen collection
Entry Date(s):
Date Created: 20210107 Date Completed: 20210408 Latest Revision: 20210408
Update Code:
20240105
DOI:
10.1099/jmm.0.001302
PMID:
33410733
Czasopismo naukowe
In recent decades there has been an increase in knowledge of the distribution, species diversity and growth patterns of bacteria in human chronic infections. This has challenged standard diagnostic methods, which have undergone a development to both increase the accuracy of testing as well as to decrease the occurrence of contamination. In particular, the introduction of new technologies based on molecular techniques into the clinical diagnostic process has increased detection and identification of infectious pathogens. Sampling is the first step in the diagnostic process, making it crucial for obtaining a successful outcome. However, sampling methods have not developed at the same speed as molecular identification. The heterogeneous distribution and potentially small number of pathogenic bacterial cells in chronic infected tissue makes sampling a complicated task, and samples must be collected judiciously and handled with care. Clinical sampling is a step in the diagnostic process that may benefit from innovative methods based on current knowledge of bacteria present in chronic infections. In the present review, we describe and discuss different aspects that complicate sampling of chronic infections. The purpose is to survey representative scientific work investigating the presence and distribution of bacteria in chronic infections in relation to various clinical sampling methods.

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