Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Harnessing nanotechnology to expand the toolbox of chemical biology.

Tytuł :
Harnessing nanotechnology to expand the toolbox of chemical biology.
Autorzy :
Williams RM; Department of Biomedical Engineering, The City College of New York, New York, NY, USA.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chen S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Langenbacher RE; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, USA.
Galassi TV; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, USA.
Harvey JD; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, USA.
Jena PV; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Budhathoki-Uprety J; Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC, USA. .
Luo M; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, USA. .
Heller DA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, USA. .
Pokaż więcej
Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Feb; Vol. 17 (2), pp. 129-137. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
Język :
English
Imprint Name(s) :
Original Publication: New York, NY : Nature Pub. Group, [2005]-
MeSH Terms :
Molecular Biology/*trends
Nanotechnology/*trends
Animals ; Biocompatible Materials ; Drug Carriers/chemistry ; Drug Delivery Systems ; Enzymes/chemistry ; Humans ; Molecular Biology/methods ; Molecular Imaging/methods ; Nanoparticles
References :
Kreyling, W. G., Semmler-Behnke, M. & Chaudhry, Q. A complementary definition of nanomaterial. Nano Today 5, 165–168 (2010).
Anselmo, A. C. & Mitragotri, S. Nanoparticles in the clinic. Bioeng. Transl. Med. 1, 10–29 (2016). (PMID: 293130045689513)
Deu, E., Verdoes, M. & Bogyo, M. New approaches for dissecting protease functions to improve probe development and drug discovery. Nat. Struct. Mol. Biol. 19, 9–16 (2012). (PMID: 222182943513415)
Shamay, Y. et al. Quantitative self-assembly prediction yields targeted nanomedicines. Nat. Mater. 17, 361–368 (2018). (PMID: 294030545930166)
Wang, A. Z., Langer, R. & Farokhzad, O. C. Nanoparticle delivery of cancer drugs. Annu. Rev. Med. 63, 185–198 (2012). (PMID: 21888516)
Alidori, S. et al. Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury. Sci. Transl. Med. 8, 331ra339 (2016).
Bianco, A., Kostarelos, K. & Prato, M. Applications of carbon nanotubes in drug delivery. Curr. Opin. Chem. Biol. 9, 674–679 (2005). (PMID: 16233988)
Alexis, F., Pridgen, E. M., Langer, R. & Farokhzad, O. C. in Drug Delivery Handbook of Experimental Pharmacology vol. 197 (ed Schäfer-Korting, M.) 55–86 (Springer, Berlin, Heidelberg, 2010); https://doi.org/10.1007/978-3-642-00477-3_2.
Wei, X. et al. Cardinal role of intraliposome doxorubicin-sulfate nanorod crystal in doxil properties and performance. ACS Omega 3, 2508–2517 (2018). (PMID: 300238376044617)
Govender, T., Stolnik, S., Garnett, M. C., Illum, L. & Davis, S. S. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J. Control. Release 57, 171–185 (1999). (PMID: 9971898)
Yoo, H. S., Oh, J. E., Lee, K. H. & Park, T. G. Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release. Pharm. Res. 16, 1114–1118 (1999). (PMID: 10450940)
Badeau, B. A., Comerford, M. P., Arakawa, C. K., Shadish, J. A. & DeForest, C. A. Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery. Nat. Chem. 10, 251–258 (2018). (PMID: 294615285822735)
Ramasamy, T. et al. Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs. Acta Biomater. 10, 5116–5127 (2014). (PMID: 25169256)
Horcajada, P. et al. Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nat. Mater. 9, 172–178 (2010). (PMID: 20010827)
El-Sayed, A., Khalil, I. A., Kogure, K., Futaki, S. & Harashima, H. Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape. J. Biol. Chem. 283, 23450–23461 (2008). (PMID: 18550548)
Budhathoki-Uprety, J., Langenbacher, R. E., Jena, P. V., Roxbury, D. & Heller, D. A. A carbon nanotube optical sensor reports nuclear entry via a noncanonical pathway. ACS Nano 11, 3875–3882 (2017). (PMID: 283980315511501)
Yameen, B. et al. Insight into nanoparticle cellular uptake and intracellular targeting. J. Control. Release 190, 485–499 (2014). (PMID: 249840114153400)
Paulo, C. S., Pires das Neves, R. & Ferreira, L. S. Nanoparticles for intracellular-targeted drug delivery. Nanotechnology 22, 494002 (2011). (PMID: 22101232)
Lee, J. et al. Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device. Nano Lett. 12, 6322–6327 (2012). (PMID: 231457963521073)
Gradishar, W. J. et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J. Clin. Oncol. 23, 7794–7803 (2005). (PMID: 16172456)
Shamay, Y. et al. P-selectin is a nanotherapeutic delivery target in the tumor microenvironment. Sci. Transl. Med. 8, 345ra387 (2016).
Almeida, J. P. M., Chen, A. L., Foster, A. & Drezek, R. In vivo biodistribution of nanoparticles. Nanomedicine (Lond.) 6, 815–835 (2011).
Jokerst, J. V., Lobovkina, T., Zare, R. N. & Gambhir, S. S. Nanoparticle PEGylation for imaging and therapy. Nanomedicine (Lond.) 6, 715–728 (2011).
Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387–6392 (1986). (PMID: 2946403)
Wang, J. et al. The combined effects of size and surface chemistry on the accumulation of boronic acid-rich protein nanoparticles in tumors. Biomaterials 35, 866–878 (2014). (PMID: 24157313)
Prabhakar, U. et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res. 73, 2412–2417 (2013). (PMID: 234239793916009)
Schroeder, A. et al. Treating metastatic cancer with nanotechnology. Nat. Rev. Cancer 12, 39–50 (2011). (PMID: 22193407)
Burns, A. A. et al. Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano Lett. 9, 442–448 (2009). (PMID: 190994556262890)
Williams, R. M. et al. Mesoscale nanoparticles selectively target the renal proximal tubule epithelium. Nano Lett. 15, 2358–2364 (2015). (PMID: 258113534518714)
Williams, R. M. et al. Selective nanoparticle targeting of the renal tubules. Hypertension 71, 87–94 (2018). (PMID: 29133360)
Choi, C. H. J., Zuckerman, J. E., Webster, P. & Davis, M. E. Targeting kidney mesangium by nanoparticles of defined size. Proc. Natl. Acad. Sci. USA 108, 6656–6661 (2011). (PMID: 21464325)
Deshmukh, M. et al. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J. Control. Release 164, 65–73 (2012). (PMID: 23041417)
Sharma, R., Saxena, D., Dwivedi, A. K. & Misra, A. Inhalable microparticles containing drug combinations to target alveolar macrophages for treatment of pulmonary tuberculosis. Pharm. Res. 18, 1405–1410 (2001). (PMID: 11697465)
Mistry, A., Stolnik, S. & Illum, L. Nanoparticles for direct nose-to-brain delivery of drugs. Int. J. Pharm. 379, 146–157 (2009). (PMID: 19555750)
D’Addio, S. M. & Prud’homme, R. K. Controlling drug nanoparticle formation by rapid precipitation. Adv. Drug Deliv. Rev. 63, 417–426 (2011). (PMID: 21565233)
Geng, Y. et al. Shape effects of filaments versus spherical particles in flow and drug delivery. Nat. Nanotechnol. 2, 249–255 (2007). (PMID: 186542712740330)
Gratton, S. E. et al. Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. J. Control. Release 121, 10–18 (2007). (PMID: 176435441994820)
Wang, A. Z. et al. Biofunctionalized targeted nanoparticles for therapeutic applications. Expert Opin. Biol. Ther. 8, 1063–1070 (2008). (PMID: 186137593515649)
Silpe, J. E. et al. Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticles. ACS Chem. Biol. 8, 2063–2071 (2013). (PMID: 238554783783574)
Schmid, D. et al. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat. Comm. 8, 1747 (2017).
Panyam, J. & Labhasetwar, V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55, 329–347 (2003). (PMID: 12628320)
Cheng, Q. et al. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Nat. Nanotechnol. 15, 313–320 (2020). (PMID: 322513837735425)
Adams, D. et al. Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis. N. Engl. J. Med. 379, 11–21 (2018). (PMID: 29972753)
Yusop, R. M., Unciti-Broceta, A., Johansson, E. M., Sánchez-Martín, R. M. & Bradley, M. Palladium-mediated intracellular chemistry. Nat. Chem. 3, 239–243 (2011). (PMID: 21336331)
Tonga, G. Y. et al. Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts. Nat. Chem. 7, 597–603 (2015). (PMID: 261008095697749)
Islam, M. A. et al. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nat. Biomed. Eng. 2, 850–864 (2018). (PMID: 310156146486184)
Xie, R., Hong, S., Feng, L., Rong, J. & Chen, X. Cell-selective metabolic glycan labeling based on ligand-targeted liposomes. J. Am. Chem. Soc. 134, 9914–9917 (2012). (PMID: 22646989)
Sun, Y. et al. Mechanistic investigation and multiplexing of liposome-assisted metabolic glycan labeling. J. Am. Chem. Soc. 140, 3592–3602 (2018). (PMID: 294466316031147)
Crespilho, F. N., Iost, R. M., Travain, S. A., Oliveira, O. N. Jr. & Zucolotto, V. Enzyme immobilization on Ag nanoparticles/polyaniline nanocomposites. Biosens. Bioelectron. 24, 3073–3077 (2009). (PMID: 19427191)
Choi, H.-J. & Montemagno, C. D. Artificial organelle: ATP synthesis from cellular mimetic polymersomes. Nano Lett. 5, 2538–2542 (2005). (PMID: 16351211)
Kudina, O. et al. Highly efficient phase boundary biocatalysis with enzymogel nanoparticles. Angew. Chem. Int. Edn Engl. 53, 483–487 (2014).
Lian, X., Erazo-Oliveras, A., Pellois, J. P. & Zhou, H. C. High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks. Nat. Commun. 8, 2075 (2017). (PMID: 292340275727123)
Jordan, P. C. et al. Self-assembling biomolecular catalysts for hydrogen production. Nat. Chem. 8, 179–185 (2016). (PMID: 26791902)
Wijnands, S. P. W., Engelen, W., Lafleur, R. P. M., Meijer, E. W. & Merkx, M. Controlling protein activity by dynamic recruitment on a supramolecular polymer platform. Nat. Commun. 9, 65 (2018). (PMID: 293020545754363)
Ke, G. et al. Directional regulation of enzyme pathways through the control of substrate channeling on a DNA origami scaffold. Angew. Chem. Int. Edn Engl. 55, 7483–7486 (2016).
Jiang, D. et al. Nanozyme: new horizons for responsive biomedical applications. Chem. Soc. Rev. 48, 3683–3704 (2019). (PMID: 311192586696937)
Dong, H., Fan, Y., Zhang, W., Gu, N. & Zhang, Y. Catalytic mechanisms of nanozymes and their applications in biomedicine. Bioconjug. Chem. 30, 1273–1296 (2019). (PMID: 30966739)
Park, S. M., Aalipour, A., Vermesh, O., Yu, J. H. & Gambhir, S. S. Towards clinically translatable in vivo nanodiagnostics. Nat. Rev. Mater. 2, 17014 (2017). (PMID: 298761375985817)
Benezra, M. et al. Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. J. Clin. Invest. 121, 2768–2780 (2011). (PMID: 216704973223837)
Chen, M. J. & Yin, M. Z. Design and development of fluorescent nanostructures for bioimaging. Prog. Polym. Sci. 39, 365–395 (2014).
Medintz, I. L., Uyeda, H. T., Goldman, E. R. & Mattoussi, H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 4, 435–446 (2005). (PMID: 15928695)
Michalet, X. et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538–544 (2005). (PMID: 1568137615681376)
Heller, D. A., Baik, S., Eurell, T. E. & Strano, M. S. Single‐walled carbon nanotube spectroscopy in live cells: towards long‐term labels and optical sensors. Adv. Mater. 17, 2793–2799 (2005).
O’Connell, M. J. et al. Band gap fluorescence from individual single-walled carbon nanotubes. Science 297, 593–596 (2002). (PMID: 12142535)
Wen, J., Xu, Y., Li, H., Lu, A. & Sun, S. Recent applications of carbon nanomaterials in fluorescence biosensing and bioimaging. Chem. Commun. (Camb.) 51, 11346–11358 (2015).
Ghosh, D. et al. Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proc. Natl. Acad. Sci. USA 111, 13948–13953 (2014). (PMID: 25214538)
Godin, A. G. et al. Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain. Nat. Nanotechnol. 12, 238–243 (2017). (PMID: 27870840)
Lim, S. Y., Shen, W. & Gao, Z. Carbon quantum dots and their applications. Chem. Soc. Rev. 44, 362–381 (2015). (PMID: 25316556)
Hemelaar, S. R. et al. Nanodiamonds as multi-purpose labels for microscopy. Sci. Rep. 7, 720 (2017). (PMID: 283896525429637)
Fox, M. D. & Raichle, M. E. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat. Rev. Neurosci. 8, 700–711 (2007). (PMID: 1770481217704812)
Estelrich, J., Sánchez-Martín, M. J. & Busquets, M. A. Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents. Int. J. Nanomedicine 10, 1727–1741 (2015). (PMID: 258344224358688)
Thakor, A. S. et al. Clinically approved nanoparticle imaging agents. J. Nucl. Med. 57, 1833–1837 (2016). (PMID: 277380075126695)
Popovtzer, R. et al. Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett. 8, 4593–4596 (2008). (PMID: 193678072772154)
Pérez-Medina, C. et al. A modular labeling strategy for in vivo PET and near-infrared fluorescence imaging of nanoparticle tumor targeting. J. Nucl. Med. 55, 1706–1711 (2014). (PMID: 250601964381653)
Xie, J. et al. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 31, 3016–3022 (2010). (PMID: 200928872838491)
Lei, J. & Ju, H. Signal amplification using functional nanomaterials for biosensing. Chem. Soc. Rev. 41, 2122–2134 (2012). (PMID: 22278386)
Liu, Z. et al. Multiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube raman tags in the near-infrared. Nano Res. 3, 222–233 (2010). (PMID: 214420063062899)
Li, Y., Wang, Z., Mu, X., Ma, A. & Guo, S. Raman tags: novel optical probes for intracellular sensing and imaging. Biotechnol. Adv. 35, 168–177 (2017). (PMID: 28017904)
Li, S. et al. Dual-mode ultrasensitive quantification of microRNA in living cells by chiroplasmonic nanopyramids self-assembled from gold and upconversion nanoparticles. J. Am. Chem. Soc. 138, 306–312 (2016). (PMID: 26691742)
Maxwell, D. J., Taylor, J. R. & Nie, S. Self-assembled nanoparticle probes for recognition and detection of biomolecules. J. Am. Chem. Soc. 124, 9606–9612 (2002). (PMID: 12167056)
Gao, Y., Shi, J., Yuan, D. & Xu, B. Imaging enzyme-triggered self-assembly of small molecules inside live cells. Nat. Commun. 3, 1033 (2012). (PMID: 229297903521559)
Mu, C. J., Lavan, D. A., Langer, R. S. & Zetter, B. R. Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo. ACS Nano 4, 1511–1520 (2010). (PMID: 201465062847389)
Ling, D. et al. Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors. J. Am. Chem. Soc. 136, 5647–5655 (2014). (PMID: 24689550)
Kruss, S. et al. High-resolution imaging of cellular dopamine efflux using a fluorescent nanosensor array. Proc. Natl. Acad. Sci. USA 114, 1789–1794 (2017). (PMID: 28179565)
Beyene, A. G. et al. Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor. Sci. Adv. 5, eaaw3108 (2019). (PMID: 313091476620097)
Williams, R. M., Lee, C. & Heller, D. A. A fluorescent carbon nanotube sensor detects the metastatic prostate cancer biomarker uPA. ACS Sens. 3, 1838–1845 (2018). (PMID: 30169018)
Chang, H., Tang, L., Wang, Y., Jiang, J. & Li, J. Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection. Anal. Chem. 82, 2341–2346 (2010). (PMID: 20180560)
Rasheed, P. A. & Sandhyarani, N. Carbon nanostructures as immobilization platform for DNA: a review on current progress in electrochemical DNA sensors. Biosens. Bioelectron. 97, 226–237 (2017). (PMID: 28601788)
Hahm, J.-i & Lieber, C. M. Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett. 4, 51–54 (2004).
Feng, L., Chen, Y., Ren, J. & Qu, X. A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells. Biomaterials 32, 2930–2937 (2011). (PMID: 21256585)
Jena, P. V. et al. A carbon nanotube optical reporter maps endolysosomal lipid flux. ACS Nano 11, 10689–10703 (2017). (PMID: 288980555707631)
Galassi, T. V. et al. An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo. Sci. Transl. Med. 10, eaar2680 (2018). (PMID: 302826946543545)
Harvey, J. D. et al. A carbon nanotube reporter of microRNA hybridization events in vivo. Nat. Biomed. Eng. 1, 0041 (2017). (PMID: 288453375568023)
Iverson, N. M. et al. In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes. Nat. Nanotechnol. 8, 873–880 (2013). (PMID: 241859424066962)
Williams, R. M. et al. Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant. Sci. Adv. 4, eaaq1090 (2018). (PMID: 296754695906074)
Chang, P. V. et al. Copper-free click chemistry in living animals. Proc. Natl. Acad. Sci. USA 107, 1821–1826 (2010). (PMID: 20080615)
Li, J., Jia, S. & Chen, P. R. Diels-Alder reaction-triggered bioorthogonal protein decaging in living cells. Nat. Chem. Biol. 10, 1003–1005 (2014). (PMID: 25362360)
Roxbury, D. et al. Hyperspectral microscopy of near-infrared fluorescence enables 17-chirality carbon nanotube imaging. Sci. Rep. 5, 14167 (2015). (PMID: 263874824585673)
Grant Information :
R01 GM120570 United States GM NIGMS NIH HHS; P30 CA008748 United States CA NCI NIH HHS; R35 GM124878 United States GM NIGMS NIH HHS; R01 DK114321 United States DK NIDDK NIH HHS; R01 CA215719 United States CA NCI NIH HHS; UL1 TR002384 United States TR NCATS NIH HHS; R35 GM131858 United States GM NIGMS NIH HHS; DP2 HD075698 United States HD NICHD NIH HHS; R01 NS116353 United States NS NINDS NIH HHS; R01 GM096056 United States GM NIGMS NIH HHS
Substance Nomenclature :
0 (Biocompatible Materials)
0 (Drug Carriers)
0 (Enzymes)
Entry Date(s) :
Date Created: 20210108 Date Completed: 20210308 Latest Revision: 20210414
Update Code :
20210414
DOI :
10.1038/s41589-020-00690-6
PMID :
33414556
Czasopismo naukowe
Although nanotechnology often addresses biomedical needs, nanoscale tools can also facilitate broad biological discovery. Nanoscale delivery, imaging, biosensing, and bioreactor technologies may address unmet questions at the interface between chemistry and biology. Currently, many chemical biologists do not include nanomaterials in their toolbox, and few investigators develop nanomaterials in the context of chemical tools to answer biological questions. We reason that the two fields are ripe with opportunity for greater synergy. Nanotechnologies can expand the utility of chemical tools in the hands of chemical biologists, for example, through controlled delivery of reactive and/or toxic compounds or signal-binding events of small molecules in living systems. Conversely, chemical biologists can work with nanotechnologists to address challenging biological questions that are inaccessible to both communities. This Perspective aims to introduce the chemical biology community to nanotechnologies that may expand their methodologies while inspiring nanotechnologists to address questions relevant to chemical biology.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies