Management of refractory pain in Stiff-Person syndrome.

Szczegóły
Abstrakt

Tytuł:: Management of refractory pain in Stiff-Person syndrome.
Autorzy:: Cirnigliaro FA; Acute Pain Service, Northern Hospital, Epping, Victoria, Australia .
Gauthier N; Acute Pain Service, Northern Hospital, Epping, Victoria, Australia.
Rush M; Acute Pain Service, Northern Hospital, Epping, Victoria, Australia.
Źródło:: BMJ case reports [BMJ Case Rep] 2021 Jan 11; Vol. 14 (1). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BMJ Pub. Group
MeSH Terms:: Muscle Spasticity/*drug therapy
Pain Management/*methods
Pain, Intractable/*drug therapy
Stiff-Person Syndrome/*complications
Adult ; Analgesia, Patient-Controlled/methods ; Analgesics/administration & dosage ; Anticonvulsants/administration & dosage ; Female ; Humans ; Magnesium Sulfate/administration & dosage ; Muscle Relaxants, Central/administration & dosage ; Muscle Spasticity/diagnosis ; Muscle Spasticity/etiology ; Muscle Spasticity/rehabilitation ; Pain Measurement ; Pain, Intractable/diagnosis ; Pain, Intractable/etiology ; Pain, Intractable/rehabilitation ; Severity of Illness Index ; Stiff-Person Syndrome/diagnosis
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Contributed Indexing:: Keywords: drugs: CNS (not psychiatric); neurology (drugs and medicines); pain; pain (neurology)
Substance Nomenclature:: 0 (Analgesics)
0 (Anticonvulsants)
0 (Muscle Relaxants, Central)
7487-88-9 (Magnesium Sulfate)
Entry Date(s):: Date Created: 20210112 Date Completed: 20210222 Latest Revision: 20230112
Update Code:: 20240105
PubMed Central ID:: PMC7802698
DOI:: 10.1136/bcr-2020-237814
PMID:: 33431538
: Czasopismo naukowe

Stiff-Person syndrome (SPS) is a rare autoimmune neurological disorder characterised by episodic painful muscle rigidity and violent spasms. A significant trigger for the painful spasms experienced by patients is pain itself, making optimal pain management and avoidance a necessity. While first-line and second-line therapies for spasm prevention and termination are known, there is a paucity of evidence to guide pain management. We report the case of a 26-year-old woman with SPS referred for excruciating muscle cramping and rigidity with pain lasting beyond the episodes themselves. We report the novel use of ketamine and intravenous magnesium sulfate which may provide analgesia, spasm avoidance and early termination of exacerbations in SPS.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.)

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