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Tytuł pozycji:

A historical perspective on the interactions of insulin at the blood-brain barrier.

Tytuł :
A historical perspective on the interactions of insulin at the blood-brain barrier.
Autorzy :
Rhea EM; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Banks WA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
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Źródło :
Journal of neuroendocrinology [J Neuroendocrinol] 2021 Apr; Vol. 33 (4), pp. e12929. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Publication: <2010->: Malden, MA : Wiley & Sons
Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989-
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Grant Information :
R01 AG046619 United States AG NIA NIH HHS; Diabetes Research Center, University of Washington; RO1AG046619 United States RG CSR NIH HHS; RF1 AG059088 United States AG NIA NIH HHS; RF1AG059088 United States RG CSR NIH HHS
Contributed Indexing :
Keywords: blood-brain barrier; insulin; insulin receptor; pharmacokinetics
Entry Date(s) :
Date Created: 20210112 Latest Revision: 20210420
Update Code :
20210420
PubMed Central ID :
PMC8052275
DOI :
10.1111/jne.12929
PMID :
33433042
Czasopismo naukowe
Subsequent to the discovery of insulin in 1921, the role of insulin in the brain has been investigated throughly. The ability of insulin to act within the brain to regulate peripheral glucose levels helped evolve the research surrounding the ability of insulin to be transported into the brain. Investigations aiming to determine the transport of insulin into the brain from the circulation soon followed. Once it was established that insulin could enter the brain, the ability of insulin to bind brain microvessels and regulators of this process were determined. As technology advanced, quantitative measurements to specify the transport rate of insulin across the blood-brain barrier (BBB) and the impact of physiological conditions and diseases were the logical next steps. Lastly, with the advent of genetic mouse models and high-specificity antagonists, the specific role of the insulin receptor in mediating insulin transport could begin to be explored. In this review, we summarise the main findings throughout the decades regarding the interactions of insulin at the BBB.
(© 2020 British Society for Neuroendocrinology.)

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