Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.

Tytuł:: Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.
Autorzy:: Rath-Deschner B; Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Nogueira AVB; Department of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.
Memmert S; Department of Orthodontics and Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Nokhbehsaim M; Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Augusto Cirelli J; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University, UNESP, Araraquara 14801-903, Brazil.
Eick S; Department of Periodontology, Laboratory for Oral Microbiology, zmk bern, Zahnmedizinische Kliniken, 53010 Bern, Switzerland.
Miosge N; Department of Prosthodontics, University Medical Center, 37075 Goettingen, Germany.
Kirschneck C; Department of Orthodontics, University of Regensburg, 93053 Regensburg, Germany.
Kesting M; Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Deschner J; Department of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.
Jäger A; Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Damanaki A; Department of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 08; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 08.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Gene Expression Regulation*
Baculoviral IAP Repeat-Containing 3 Protein/*genetics
Periodontal Ligament/*metabolism
Periodontium/*metabolism
Superoxide Dismutase/*genetics
Animals ; Apoptosis/genetics ; Baculoviral IAP Repeat-Containing 3 Protein/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cells, Cultured ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fusobacterium nucleatum/physiology ; Gingiva/cytology ; Gingiva/metabolism ; Host-Pathogen Interactions ; Humans ; Periodontal Ligament/cytology ; Periodontal Ligament/microbiology ; Periodontium/cytology ; Periodontium/microbiology ; Rats ; Superoxide Dismutase/metabolism
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Grant Information:: DE1593/5-1 Deutsche Forschungsgemeinschaft; 57391253 Deutscher Akademischer Austauschdienst; 2017/07137-2 São Paulo Research Foundation; 88881.144012/2017-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; none German Society of Orthodontics
Contributed Indexing:: Keywords: Fusobacterium nucleatum; gingivitis; orthodontic tooth movement; periodontal ligament; periodontitis; periodontium
Substance Nomenclature:: EC 1.15.1.1 (Superoxide Dismutase)
EC 1.15.1.1 (superoxide dismutase 2)
EC 2.3.2.27 (Baculoviral IAP Repeat-Containing 3 Protein)
EC 3.4.22.- (Caspase 3)
EC 3.4.22.- (Caspase 9)
Entry Date(s):: Date Created: 20210113 Date Completed: 20210329 Latest Revision: 20210329
Update Code:: 20240105
PubMed Central ID:: PMC7827060
DOI:: 10.3390/ijms22020591
PMID:: 33435582
: Czasopismo naukowe

Pełny tekst

The aim of the study was to clarify whether orthodontic forces and periodontitis interact with respect to the anti-apoptotic molecules superoxide dismutase 2 (SOD2) and baculoviral IAP repeat-containing protein 3 (BIRC3). SOD2, BIRC3, and the apoptotic markers caspases 3 (CASP3) and 9 (CASP9) were analyzed in gingiva from periodontally healthy and periodontitis subjects by real-time PCR and immunohistochemistry. SOD2 and BIRC3 were also studied in gingiva from rats with experimental periodontitis and/or orthodontic tooth movement. Additionally, SOD2 and BIRC3 levels were examined in human periodontal fibroblasts incubated with Fusobacterium nucleatum and/or subjected to mechanical forces. Gingiva from periodontitis patients showed significantly higher SOD2, BIRC3, CASP3, and CASP9 levels than periodontally healthy gingiva. SOD2 and BIRC3 expressions were also significantly increased in the gingiva from rats with experimental periodontitis, but the upregulation of both molecules was significantly diminished in the concomitant presence of orthodontic tooth movement. In vitro, SOD2 and BIRC3 levels were significantly increased by F. nucleatum , but this stimulatory effect was also significantly inhibited by mechanical forces. Our study suggests that SOD2 and BIRC3 are produced in periodontal infection as a protective mechanism against exaggerated apoptosis. In the concomitant presence of orthodontic forces, this protective anti-apoptotic mechanism may get lost.

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