Nutritional and developmental programming effects of insulin.

Tytuł:: Nutritional and developmental programming effects of insulin.
Autorzy:: Dearden L; MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK.
Bouret SG; Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition Research Center, Lille, France.; University of Lille, Lille, France.
Ozanne SE; MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK.
Źródło:: Journal of neuroendocrinology [J Neuroendocrinol] 2021 Jan 13; Vol. 33 (4), pp. e12933. Date of Electronic Publication: 2021 Jan 13.
Publication Model:: Ahead of Print
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Publication: <2010->: Malden, MA : Wiley & Sons
Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989-
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Grant Information:: MC_UU_00014/4 United Kingdom MRC_ Medical Research Council; MC_UU_12012/4 United Kingdom MRC_ Medical Research Council; RG/17/12/33167 United Kingdom BHF_ British Heart Foundation
Contributed Indexing:: Keywords: developmental programming; diabetes; hormones; hypothalamus; obesity
Entry Date(s):: Date Created: 20210113 Latest Revision: 20240222
Update Code:: 20240223
DOI:: 10.1111/jne.12933
PMID:: 33438814
: Czasopismo naukowe

Pełny tekst

The discovery of insulin in 1921 was a major breakthrough in medicine and for therapy in patients with diabetes. The dramatic rise in the prevalence of overweight and obesity has been tightly linked to an increased prevalence of gestational diabetes mellitus (GDM), which poses major health concerns. Babies born to GDM mothers are more likely to develop obesity, type 2 diabetes and cardiovascular disease later in life. Evidence accumulated during the past two decades has revealed that high levels insulin, such as those observed during GDM, can have a widespread effect on the development and function of a variety of organs. This review summarises our current knowledge on the role of insulin in the placenta, cardiovascular system and brain during critical periods of development, as well as how it can contribute to lifelong metabolic regulation. We also discuss possible intervention strategies to ameliorate and hopefully reverse the developmental defects associated with obesity and GDM.
(© 2021 British Society for Neuroendocrinology.)

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