Possible nosocomial transmission of virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

Szczegóły
Abstrakt

Tytuł:: Possible nosocomial transmission of virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.
Autorzy:: Onda Y; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Kanda J; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. .
Hanaoka N; Center for Infectious Disease Risk Management, National Institute of Infectious Diseases, Tokyo, Japan.
Watanabe M; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Arai Y; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Hishizawa M; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Kondo T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Yamashita K; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Nagao M; Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Fujimoto T; Center for Infectious Disease Risk Management, National Institute of Infectious Diseases, Tokyo, Japan.
Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Źródło:: Annals of hematology [Ann Hematol] 2021 Mar; Vol. 100 (3), pp. 753-761. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Berlin : Springer Verlag
Original Publication: Berlin ; New York : Springer International, c1991-
MeSH Terms:: Cross Infection/*etiology
Cystitis/*virology
Hematopoietic Stem Cell Transplantation/*adverse effects
Hemorrhage/*virology
Virus Diseases/*etiology
Adenoviridae/isolation & purification ; Adenoviridae/physiology ; Adenoviridae Infections/epidemiology ; Adenoviridae Infections/etiology ; Adolescent ; Adult ; Aged ; BK Virus/isolation & purification ; BK Virus/physiology ; Cohort Studies ; Cross Infection/epidemiology ; Cystitis/epidemiology ; Cystitis/etiology ; Female ; Hematopoietic Stem Cell Transplantation/statistics & numerical data ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Humans ; JC Virus/isolation & purification ; JC Virus/physiology ; Japan/epidemiology ; Male ; Middle Aged ; Polyomavirus Infections/epidemiology ; Polyomavirus Infections/etiology ; Retrospective Studies ; Risk Factors ; Transplantation, Homologous/adverse effects ; Transplantation, Homologous/statistics & numerical data ; Tumor Virus Infections/epidemiology ; Tumor Virus Infections/etiology ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/etiology ; Virus Diseases/epidemiology ; Young Adult
References:: Gorczynska E et al (2005) Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 11(10):797–804. (PMID: 10.1016/j.bbmt.2005.06.007)
Lunde LE et al (2015) Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant 50(11):1432–1437. (PMID: 10.1038/bmt.2015.162)
Mori Y et al (2012) Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 18(3):458–465. (PMID: 10.1016/j.bbmt.2011.07.025)
Han TT et al (2014) Cytomegalovirus is a potential risk factor for late-onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation. Am J Hematol 89(1):55–61. (PMID: 10.1002/ajh.23584)
Erard V et al (2005) BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 106(3):1130–1132. (PMID: 10.1182/blood-2004-12-4988)
Leung AY et al (2005) Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 40(4):528–537. (PMID: 10.1086/427291)
Nagafuji K et al (2004) Cidofovir for treating adenoviral hemorrhagic cystitis in hematopoietic stem cell transplant recipients. Bone Marrow Transplant 34(10):909–914. (PMID: 10.1038/sj.bmt.1704682)
Sakurada M et al (2016) Successful treatment with intravesical cidofovir for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: a case report and a review of the literature. J Infect Chemother 22(7):495–500. (PMID: 10.1016/j.jiac.2016.01.013)
Suzuki S et al (2014) Successful use of endoscopic argon plasma coagulation for hemorrhagic radiation cystitis: a case report. Jpn J Clin Oncol 44(7):692–695. (PMID: 10.1093/jjco/hyu066)
Carrigan DR (1997) Adenovirus infections in immunocompromised patients. Am J Med 102(3A):71–74. (PMID: 10.1016/S0002-9343(97)00015-6)
Leung AY, Yuen KY, Kwong YL (2005) Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm. Bone Marrow Transplant 36(11):929–937. (PMID: 10.1038/sj.bmt.1705139)
Kato J et al (2017) Nosocomial BK polyomavirus infection causing hemorrhagic cystitis among patients with hematological malignancies after hematopoietic stem cell transplantation. Am J Transplant 17(9):2428–2433. (PMID: 10.1111/ajt.14271)
Koskenvuo M et al (2013) BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission. J Clin Virol 56(1):77–81. (PMID: 10.1016/j.jcv.2012.09.003)
Jalal H et al (2005) First reported outbreak of diarrhea due to adenovirus infection in a hematology unit for adults. J Clin Microbiol 43(6):2575–2580. (PMID: 10.1128/JCM.43.6.2575-2580.2005)
Sammons JS et al (2019) Outbreak of adenovirus in a neonatal intensive care unit: critical importance of equipment cleaning during inpatient ophthalmologic examinations. Ophthalmology 126(1):137–143. (PMID: 10.1016/j.ophtha.2018.07.008)
Noda N et al (1981) Virucidal activity of alcohols. Virucidal efficiency of alcohols against viruses in liquid phase (author’s transl). Kansenshogaku Zasshi 55(5):355–366. (PMID: 10.11150/kansenshogakuzasshi1970.55.355)
Noda M, Matsuda S, Kobayashi M (2000) Virucidal activity of disinfectants: virucidal activities of disinfectants on some viruses coated on several materials and its durability. Kansenshogaku Zasshi 74(12):1023–1031. (PMID: 10.11150/kansenshogakuzasshi1970.74.1023)
Droller MJ, Saral R, Santos G (1982) Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 20(3):256–258. (PMID: 10.1016/0090-4295(82)90633-1)
Nakano S et al (2017) Establishment of multiplex solid-phase strip PCR test for detection of 24 ocular infectious disease pathogens. Invest Ophthalmol Vis Sci 58(3):1553–1559. (PMID: 10.1167/iovs.16-20556)
Kimura M (1980) A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 16(2):111–120. (PMID: 10.1007/BF01731581)
Saitou N, Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4(4):406–425.
Felsenstein J (1985) Confidence limits on phylogenies: an approach using the bootstrap. evolution 39(4):783–791. (PMID: 10.1111/j.1558-5646.1985.tb00420.x)
Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 33(7):1870–1874. (PMID: 10.1093/molbev/msw054)
Wood A, Payne D (1998) The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses. J Hosp Infect 38(4):283–295. (PMID: 10.1016/S0195-6701(98)90077-9)
Echavarria M (2008) Adenoviruses in immunocompromised hosts. Clin Microbiol Rev 21(4):704–715. (PMID: 10.1128/CMR.00052-07)
Lion T (2014) Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev 27(3):441–462. (PMID: 10.1128/CMR.00116-13)
Hanaoka N et al (2019) Infectious human adenoviruses are shed in urine even after disappearance of urethral symptoms. PLoS One 14(3):e0212434. (PMID: 10.1371/journal.pone.0212434)
Yoshitomi H et al (2017) First isolation of a new type of human adenovirus (genotype 79), species Human mastadenovirus B (B2) from sewage water in Japan. J Med Virol 89(7):1192–1200. (PMID: 10.1002/jmv.24749)
Grant Information:: 10110713 the Ministry of Health, Labour, and Welfare.
Contributed Indexing:: Keywords: Adenovirus; Allogeneic transplantation; BK virus; Hemorrhagic cystitis; Nosocomial transmission
Entry Date(s):: Date Created: 20210113 Date Completed: 20210305 Latest Revision: 20210305
Update Code:: 20240105
DOI:: 10.1007/s00277-021-04414-1
PMID:: 33439306
: Czasopismo naukowe

Full Text Finder

Adenovirus (ADV)- or BK virus (BKV)-associated hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several risk factors have been previously reported; however, it is unclear whether virus-associated HC can be transmitted. To clarify this point, we performed a retrospective cohort study on 207 consecutive patients who underwent allo-HSCT at Kyoto University Hospital between 2012 and 2018. We evaluated the incidence and risk factors of virus-associated HC and performed a phylogenetic analysis of the ADV partial sequence. The median age at transplantation was 50 (range, 17-68) years. Fifty-eight patients (28%) developed HC. ADVs were detected in 18 cases, BKVs were detected in 51, both were detected in 12, and only John Cunningham virus (JCV) was detected in 1 case. No factor was significantly associated with HC. However, both ADV- and BKV-HC occurred intensively between April 2016 and September 2017, which suggested possible nosocomial transmission of ADV and BKV. Genome sequencing of the hexon, E3, and penton regions of detected ADVs identified 7 cases of ADV type 11, 2 cases of type 35, and 3 cases of a type 79-related strain. A sequence analysis revealed that these strains in each type were almost identical, except for one case of a type 79-related strain. In conclusion, ADV-HCs with possible nosocomial transmission were described based on genotyping of the virus and partial sequencing of the viral genome. Although viral HC after allo-HSCT is thought to mainly be due to reactivation of a latent virus, nosocomial transmission of ADV or BKV should also be considered.

Informacja