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Tytuł:
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Refinement of health-based guidance values for cadmium in the French population based on modelling.
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Autorzy:
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Leconte S; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 14 rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France. Electronic address: .
Rousselle C; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 14 rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France.
Bodin L; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 14 rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France.
Clinard F; Sante publique France - National Public Health Agency (ANSP) - Bourgogne-Franche-Comté Regional Unit, France.
Carne G; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 14 rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France.
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Źródło:
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Toxicology letters [Toxicol Lett] 2021 Apr 01; Vol. 340, pp. 43-51. Date of Electronic Publication: 2021 Jan 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Amsterdam, Elsevier/North Holland.
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MeSH Terms:
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Cadmium/*toxicity
Environmental Exposure/*statistics & numerical data
Environmental Pollutants/*administration & dosage
Environmental Pollutants/*toxicity
Body Burden ; Diet ; Food Contamination ; Food Safety ; France ; Humans ; Risk Assessment
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Contributed Indexing:
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Keywords: Cadmium; PB-PK model; TRV
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Substance Nomenclature:
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0 (Environmental Pollutants)
00BH33GNGH (Cadmium)
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Entry Date(s):
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Date Created: 20210113 Date Completed: 20210222 Latest Revision: 20210222
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Update Code:
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20240105
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DOI:
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10.1016/j.toxlet.2020.12.021
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PMID:
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33440227
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In France, part of the population is overexposed to cadmium by the diet. In our work, we first revised the tolerable daily intake (TDI) of 0.36 μg Cd.kg bw.d. -1 proposed by the European Food Safety Authority (EFSA), derived from effects on kidneys and based on the critical urinary Cd concentration of 1.0 μg Cd.g -1 creatinine for humans. After reviewing the epidemiological data on Cd toxicity published after 2011, bone effects were selected as the critical effects. Body burden data of 0.5 μg.g -1 creatinine was chosen for the critical threshold for human urinary cadmium concentrations. To be used for the derivation of the new oral toxicological reference value, we used a modified physiologically based pharmacokinetic model (PBPK). The reverse calculation on the PBPK model gave a TDI of 0.35 μg Cd.kg bw -1 .day -1 . This TDI is compatible with a urinary Cd concentrations not exceeding 0.5 μg Cd.g -1 creatinine, in a 60 year-old adult, assuming that ingestion is the only source of exposure to Cd at 60 years. After implementing the PBPK model with French physiological data, Cd biological reference values as a function of age were modelled so as to remain below the revised health-based guidance values.
Competing Interests: Declaration of Competing Interest The authors report no declarations of interest.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
