Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Identifying risks for severity of neurological symptoms in Hungarian West Nile virus patients.

Tytuł:
Identifying risks for severity of neurological symptoms in Hungarian West Nile virus patients.
Autorzy:
Koch M; Department of Emergency Medicine, Somogy County Kaposi Mór Teaching Hospital, Tallián Gyula Street, 20-32, Kaposvár, 7400, Hungary.
Pozsgai É; Department of Public Health, Medical School, University of Pécs, Szigeti Street, 12, Pécs, 7624, Hungary. .; Institute of Primary Health Care, Medical School, University of Pécs, Rákóczi Street 2, Pécs, 7623, Hungary. .
Soós V; Department of Emergency Medicine, Somogy County Kaposi Mór Teaching Hospital, Tallián Gyula Street, 20-32, Kaposvár, 7400, Hungary.
Nagy A; National Reference Laboratory for Viral Zoonoses; National Public Health Center, 1097 Albert Flórián Road 2-6, Budapest, Hungary.
Girán J; Department of Public Health, Medical School, University of Pécs, Szigeti Street, 12, Pécs, 7624, Hungary.
Nyisztor N; Department of Infectious Diseases (Hepatology and Immunology), Békés County Central Hospital, Semmelweis Street 1, Gyula, 5700, Hungary.
Martyin T; Department of Infectious Diseases (Hepatology and Immunology), Békés County Central Hospital, Semmelweis Street 1, Gyula, 5700, Hungary.
Müller Z; Department of Infectious Diseases, Fejér County St George Teaching Hospital, Seregélyesi Street 3, Székesfehérvár, 8000, Hungary.
Fehér M; Department of Infectious Diseases, Fejér County St George Teaching Hospital, Seregélyesi Street 3, Székesfehérvár, 8000, Hungary.
Hajdú E; Department of Infectology, University of Szeged, Albert Szent-Györgyi Health Center, Kálvária Avenue 57, Szeged, 6725, Hungary.
Varga C; Department of Emergency Medicine, Somogy County Kaposi Mór Teaching Hospital, Tallián Gyula Street, 20-32, Kaposvár, 7400, Hungary.; Institute of Emergency Care and Pedagogy of Health, Faculty of Health Sciences, University of Pécs, Vörösmarty Mihály Street 4, Pécs, 7621, Hungary.
Źródło:
BMC infectious diseases [BMC Infect Dis] 2021 Jan 13; Vol. 21 (1), pp. 65. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: London : BioMed Central, [2001-
MeSH Terms:
Coma/*etiology
Meningoencephalitis/*etiology
Paresis/*etiology
West Nile Fever/*complications
West Nile virus/*immunology
Adult ; Aged ; Comorbidity ; Female ; Follow-Up Studies ; Glasgow Coma Scale ; Humans ; Hungary/epidemiology ; Length of Stay ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; West Nile Fever/epidemiology ; West Nile Fever/virology ; West Nile virus/isolation & purification
References:
J Virol Methods. 2007 Dec;146(1-2):355-8. (PMID: 17604132)
J Gen Virol. 2011 Dec;92(Pt 12):2821-2829. (PMID: 21900425)
BMC Infect Dis. 2014 May 09;14:248. (PMID: 24884681)
JAMA. 2013 Jul 17;310(3):308-15. (PMID: 23860989)
Emerg Infect Dis. 2005 Jul;11(7):1021-7. (PMID: 16022775)
Vector Borne Zoonotic Dis. 2020 Aug;20(8):613-618. (PMID: 32228360)
CMAJ. 2003 May 27;168(11):1399-405. (PMID: 12771068)
Euro Surveill. 2019 Jul;24(28):. (PMID: 31311619)
J Clin Virol. 2020 Jan;122:104213. (PMID: 31778945)
Emerg Infect Dis. 2008 May;14(5):747-54. (PMID: 18439356)
Stroke. 2009 Oct;40(10):3393-5. (PMID: 19679846)
Am J Trop Med Hyg. 2012 Jul;87(1):179-84. (PMID: 22764311)
Emerg Infect Dis. 2007 Dec;13(12):1918-20. (PMID: 18258047)
Viruses. 2020 Jan 20;12(1):. (PMID: 31968613)
Neurorehabil Neural Repair. 2011 Jun;25(5 Suppl):33S-43S. (PMID: 21613536)
J Neurol Neurosurg Psychiatry. 1981 Apr;44(4):285-93. (PMID: 6453957)
Pathogens. 2020 Jul 19;9(7):. (PMID: 32707644)
Vet Microbiol. 2013 Jul 26;165(1-2):61-70. (PMID: 23570864)
Crit Care. 2018 Aug 17;22(1):210. (PMID: 30119686)
Stroke. 2002 Sep;33(9):2243-6. (PMID: 12215594)
JAMA. 2003 Jul 23;290(4):511-5. (PMID: 12876094)
Muscle Nerve. 2018 Jan;57(1):77-82. (PMID: 28380696)
Neurology. 1995 Jun;45(6):1115-21. (PMID: 7783874)
PLoS Negl Trop Dis. 2017 Nov 8;11(11):e0006078. (PMID: 29117195)
Neurocrit Care. 2018 Aug;29(1):47-53. (PMID: 29435806)
Ann Ist Super Sanita. 2019 Jan-Mar;55(1):3-5. (PMID: 30968829)
Int J Microbiol. 2020 May 08;2020:3513859. (PMID: 32454831)
Ann Neurol. 1980 Dec;8(6):590-6. (PMID: 7212646)
Stroke. 1988 May;19(5):604-7. (PMID: 3363593)
Vector Borne Zoonotic Dis. 2019 Nov;19(11):844-850. (PMID: 31184991)
Am J Trop Med Hyg. 2015 May;92(5):1006-1012. (PMID: 25802426)
Nat Clin Pract Neurol. 2006 May;2(5):264-75. (PMID: 16932563)
Orv Hetil. 2019 Dec;160(51):2026-2035. (PMID: 31838862)
Emerg Infect Dis. 2004 Aug;10(8):1405-11. (PMID: 15496241)
Contributed Indexing:
Keywords: Emergency department; Modified Rankin scale; Neurological outcome; West Nile neuroinvasive disease; West Nile virus infection
Entry Date(s):
Date Created: 20210114 Date Completed: 20210125 Latest Revision: 20231110
Update Code:
20240105
PubMed Central ID:
PMC7805165
DOI:
10.1186/s12879-020-05760-7
PMID:
33441090
Czasopismo naukowe
Background: West Nile virus (WNV) infections have become increasingly prevalent in certain European countries, including Hungary. Although most human infections do not cause severe symptoms, in approximately 1% of cases WNV infections can lead to severe WNV neuroinvasive disease (WNND) and death. The goal of our study was to assess the neurological status changes of WNV -infected patients admitted to inpatient care and to identify potential risk factors as underlying reasons for severe neurological outcome.
Methods: We conducted a retrospective chart review of 66 WNV-infected patients from four Hungarian medical centers. Patients' neurological status at hospital admission and at two follow-up intervals (1st follow-up, within 60-90 days and 2nd follow-up, within 150-180 days, after hospital discharge) were assessed. All of the 66 patients in the initial sample had some type of neurological symptoms and 56 patients were diagnosed with WNND. The modified Rankin Scale (mRS) and the West Nile Virus Neurological Index (WNV-N Index), a scoring system designed for the purpose of this study, were used for neurological status assessment. Patients were dichotomized into two categories, "moderately severe" and "severe" based on their neurological status. Descriptive analysis for sample description, stratified analysis for calculation of odds ratio (OR) and logistic regression for continuous input variables, were performed.
Results: The average number of days between the onset of neurological symptoms and hospital admission (the neurological symptom interval) was 6.01 days. Complications during the hospital stay arose in almost a fifth of the patients (18.2%) and 5 patients died. Each day's increase in the neurological symptom interval significantly increased the risk for developing a severe neurological status following hospital admission (0.799-fold and 0.688-fold, based on the WNV-N Index and mRS, respectively). Patients' age, comorbidity, presence of complications and symptoms of malaise, and gait uncertainty were shown to be independent risk factors for severe neurological status.
Conclusions: Timely hospital admission of patients with neurological symptoms as well as risk assessment by clinicians - possibly with an optimal assessment tool for estimating neurological status- could improve the neurological outcome of WNV-infected patients.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies