Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000-2016.

Tytuł:: Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000-2016.
Autorzy:: Silverberg JI; Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.; Department of Dermatology, The Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Warshaw EM; Department of Dermatology, Park Nicollet Health Services, Minneapolis, MN, USA.; Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA.
Maibach HI; Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
DeKoven JG; Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
Taylor JS; Department of Dermatology, Cleveland Clinic, OH, USA.
Atwater AR; Department of Dermatology, Duke University Medical Center, Durham, NC, USA.
Sasseville D; Division of Dermatology, Montreal General Hospital, McGill University, Montreal, QC, Canada.
Zug KA; Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Reeder MJ; Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Fowler JF Jr; Division of Dermatology, University of Louisville, KY, USA.
Pratt MD; Division of Dermatology, University of Ottawa, ON, Canada.
Fransway AF; Associates in Dermatology, Fort Myers, FL, USA.
Zirwas MJ; Department of Dermatology, Ohio State University, Columbus, OH, USA.
Belsito DV; Department of Dermatology, Columbia University, New York, NY, USA.
Marks JG Jr; Department of Dermatology, Pennsylvania State University, State College, PA, USA.
DeLeo VA; Department of Dermatology, Keck School of Medicine, Los Angeles, CA, USA.
Źródło:: The British journal of dermatology [Br J Dermatol] 2021 Jul; Vol. 185 (1), pp. 185-194. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2023- : Oxford : Oxford University Press
Original Publication: Oxford [etc.] Published for the British Association of Dermatologists by Blackwell Scientific Publications [etc.]
MeSH Terms:: Dermatitis, Allergic Contact*/diagnosis
Dermatitis, Allergic Contact*/epidemiology
Dermatitis, Allergic Contact*/etiology
Eczema*/chemically induced
Eczema*/diagnosis
Eczema*/epidemiology
Adolescent ; Allergens/adverse effects ; Child ; Humans ; North America/epidemiology ; Patch Tests ; Retrospective Studies
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Substance Nomenclature:: 0 (Allergens)
Entry Date(s):: Date Created: 20210117 Date Completed: 20210726 Latest Revision: 20210726
Update Code:: 20240105
DOI:: 10.1111/bjd.19818
PMID:: 33454963
: Czasopismo naukowe

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Background: Little is known about the aetiologies and relevant allergens in paediatric patients with hand eczema (HE).
Objectives: To characterize the aetiologies and determine the proportion of positive and currently relevant allergens in children/adolescents (age < 18 years) with HE referred for patch testing.
Methods: A retrospective analysis (2000-2016) of North American Contact Dermatitis Group data was performed.
Results: Of 1634 paediatric patients, 237 (14·5%) had involvement of the hands. Final physician diagnoses included allergic contact dermatitis (49·4%), atopic dermatitis (37·1%) and irritant contact dermatitis (16·9%). In multivariable logistic regression models, employment was the only association with increased odds of any HE or primary HE. Children with HE vs. those without HE had similar proportions of positive patch tests (56·1% vs. 61·7%; χ 2 -test, P = 0·11). The five most common currently relevant allergens were nickel, methylisothiazolinone, propylene glycol, decyl glucoside and lanolin. In multivariable logistic regression models of the top 20 relevant allergens, HE was associated with significantly higher odds of currently relevant reactions to lanolin, quaternium-15, Compositae mix, thiuram mix, 2-mercaptobenzathiazole and colophony. The allergens with the highest mean significance-prevalence index number were methylisothiazolinone, carba mix, thiuram mix, nickel and methylchloroisothiazolinone/methylisothiazolinone.
Conclusions: Children with HE who were referred for patch testing had a high proportion of positive patch tests, which was similar to the proportion found in children without HE. Children with HE had a distinct and fairly narrow profile of currently relevant allergens.
(© 2021 British Association of Dermatologists.)

Comment in: Br J Dermatol. 2021 Jul;185(1):17-18. (PMID: 33942284)

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