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Tytuł pozycji:

Draize human repeat insult patch test (HRIPT): Seven decades of pitfalls and progress.

Tytuł :
Draize human repeat insult patch test (HRIPT): Seven decades of pitfalls and progress.
Autorzy :
Bormann JL; University of South Dakota, Sanford School of Medicine, Sioux Falls, SD, 57105, USA. Electronic address: .
Maibach HI; UCSF, Dermatology Department, San Francisco, CA, 94143-0989, USA. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Apr; Vol. 121, pp. 104867. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
Contributed Indexing :
Keywords: Allergic contact dermatitis; Contact dermatitis; Draize human repeat insult patch testing
Entry Date(s) :
Date Created: 20210118 Latest Revision: 20210301
Update Code :
20210301
DOI :
10.1016/j.yrtph.2021.104867
PMID :
33460686
Czasopismo naukowe
Allergic contact dermatitis, a Type IV delayed hypersensitivity reaction, can result in dermatologic signs/symptoms for patients/workers. The likelihood of this phenomenon has been estimated/predicted for numerous chemicals/drugs by animal model and human patch testing protocols developed over the last century. Karl Landsteiner initiated testing with guinea pig studies; further studies based on his initial concept were in continual development. John Draize extended Landsteiner's guinea pig studies (which led to development of blood transfusions) to a human assay documenting irritant and allergic contact dermatitis potential - for drugs, chemicals, mixtures and products. We performed a literature search of major Draize derived protocols of the human repeat insult patch test (HRIPT). Our results reveal minor and major differences between protocols and lack of international standardization. Key clarification and principles post-Draize modified and improved usefulness of the HRIPT. Without a standard method of performing the HRIPT, it is problematic to generalize results of studies summarized here. Furthermore, we suggest a potential standardization procedure/protocol combining the work of the most satisfactory HRIPT methods. As the HRIPT constitutes a key parameter in current quantitative risk assessment for chemicals/drugs, such standardization should aid potential prediction of allergic contact dermatitis potential.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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