Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.

Tytuł :
Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.
Autorzy :
Swanstrom AE; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Immonen TT; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Oswald K; AIDS Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Pyle C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Thomas JA; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Bosche WJ; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Silipino L; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Hull M; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Newman L; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Coalter V; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Wiles A; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Wiles R; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Kiser J; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Morcock DR; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Shoemaker R; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Fast R; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Breed MW; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Kramer J; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Donohue D; DMS Applied Information & Management Sciences, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Malys T; DMS Applied Information & Management Sciences, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Trubey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Estes JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Del Prete GQ; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, United States of America.
Pokaż więcej
Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Jan 19. Date of Electronic Publication: 2021 Jan 19.
Publication Model :
Ahead of Print
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
Contributed Indexing :
Keywords: AIDS/HIV; T cells
Entry Date(s) :
Date Created: 20210119 Latest Revision: 20210119
Update Code :
20210210
DOI :
10.1172/JCI142421
PMID :
33465055
Czasopismo naukowe
The effectiveness of virus-specific strategies, including administered HIV-specific mAbs, to target cells that persistently harbor latent, rebound competent HIV genomes during combination antiretroviral therapy (cART) has been limited by inefficient induction of viral protein expression. To examine antibody-mediated viral reservoir targeting without a need for viral induction, we used an anti-CD4 mAb to deplete both infected and uninfected CD4+ T cells. Ten rhesus macaques infected with barcoded SIVmac239M received cART for 93 weeks starting 4 days post-infection. During cART, five animals received 5-6 anti-CD4 antibody administrations and CD4+ T cell populations were then allowed one year on cART to recover. Despite profound CD4+ T cell depletion in blood and lymph nodes, time to viral rebound following cART cessation was not significantly delayed in anti-CD4 treated animals compared with controls. Viral reactivation rates, determined based on rebounding SIVmac239M clonotype proportions, also were not significantly different in CD4 depleted animals. Notably, antibody-mediated depletion was limited in rectal tissue and negligible in lymphoid follicles. These results suggest that even if robust viral reactivation can be achieved, antibody-mediated viral reservoir depletion may be limited in key tissue sites.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies