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Tytuł pozycji:

Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.

Tytuł:
Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.
Autorzy:
Gordin M; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Philip H; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Zilberberg A; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Gidoni M; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
Margalit R; Science in Action Ltd., Ness Ziona, Israel.
Clouser C; Juno Therapeutics, Seattle, Washington, United States of America.
Adams K; Juno Therapeutics, Seattle, Washington, United States of America.
Vigneault F; Juno Therapeutics, Seattle, Washington, United States of America.
Cohen IR; Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Yaari G; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
Efroni S; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Jan 19; Vol. 17 (1), pp. e1008486. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: San Francisco, CA : Public Library of Science, [2005]-
MeSH Terms:
Breast Neoplasms*/genetics
Breast Neoplasms*/immunology
Breast Neoplasms*/metabolism
Receptors, Antigen, T-Cell*/chemistry
Receptors, Antigen, T-Cell*/genetics
Receptors, Antigen, T-Cell*/metabolism
Complementarity Determining Regions/*genetics
Animals ; Cells, Cultured ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/metabolism ; Databases, Genetic ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Mice, Transgenic ; T-Lymphocytes
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Substance Nomenclature:
0 (Complementarity Determining Regions)
0 (Receptors, Antigen, T-Cell)
Entry Date(s):
Date Created: 20210119 Date Completed: 20210514 Latest Revision: 20210514
Update Code:
20240105
PubMed Central ID:
PMC7846026
DOI:
10.1371/journal.pcbi.1008486
PMID:
33465095
Czasopismo naukowe
The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients contain antigen receptors able to specifically identify tumor cells. Here we focused on T-cell receptor (TCR) repertoires associated with spontaneous breast cancer. We studied the alpha and beta chain CDR3 domains of TCR repertoires of CD4 T cells using deep sequencing of cell populations in mice and applied the results to published TCR sequence data obtained from human patients. We screened peripheral blood T cells obtained monthly from individual mice spontaneously developing breast tumors by 5 months. We then looked at identical TCR sequences in published human studies; we used TCGA data from tumors and healthy tissues of 1,256 breast cancer resections and from 4 focused studies including sequences from tumors, lymph nodes, blood and healthy tissues, and from single cell dataset of 3 breast cancer subjects. We now report that mice spontaneously developing breast cancer manifest shared, Public CDR3 regions in both their alpha and beta and that a significant number of women with early breast cancer manifest identical CDR3 sequences. These findings suggest that the development of breast cancer is associated, across species, with biomarker, exclusive TCR repertoires.
Competing Interests: The authors have declared that no competing interests exist.
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