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Tytuł pozycji:

Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study.

Tytuł :
Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study.
Autorzy :
Matsumoto M; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan. Electronic address: .
Yamano S; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Senoh H; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Umeda Y; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Hirai S; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Saito A; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Kasai T; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Aiso S; Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan.
Pokaż więcej
Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Apr; Vol. 121, pp. 104863. Date of Electronic Publication: 2021 Jan 17.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
Contributed Indexing :
Keywords: Acrolein; Carcinogenicity; Chronic toxicity; Mice; Nasal cavity; Rats
Entry Date(s) :
Date Created: 20210119 Latest Revision: 20210301
Update Code :
20210301
DOI :
10.1016/j.yrtph.2021.104863
PMID :
33465397
Czasopismo naukowe
The carcinogenicity and chronic toxicity of acrolein was examined by whole body inhalation to groups of 50 F344/DuCrlCrlj rats and 50 B6D2F1/Crlj mice of both sexes for two years. The concentration of acrolein was 0, 0.1, 0.5 or 2 ppm (v/v) for male and female rats; and 0, 0.1, 0.4 or 1.6 ppm for male and female mice. Two-year administration of acrolein induced the squamous cell carcinomas in nasal cavity which is rare tumor in one male and two female rats. In females, rhabdomyoma in nasal cavity was observed in four rats exposed to 2 ppm. In mice, since the survival rate of male and female of mice control group were lowered than 25% in late of the administration periods due to renal lesion and/or amyloid deposition, the mice study was terminated at 93rd week in males, and was terminated at 99th week in females. The incidences of adenomas in nasal cavity were observed in 16 females and significantly increased only in female mice. Thus, acrolein is carcinogenic in two species, i.e. rats and mice. Additionally, non-neoplastic nasal cavity lesions in rats and mice were observed.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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