Associations between diet, the gut microbiome and short chain fatty acids in youth with islet autoimmunity and type 1 diabetes.

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Abstrakt

Tytuł:: Associations between diet, the gut microbiome and short chain fatty acids in youth with islet autoimmunity and type 1 diabetes.
Autorzy:: Harbison JE; Women's and Children's Hospital, Adelaide, South Australia, Australia.; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Thomson RL; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Wentworth JM; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Louise J; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Roth-Schulze A; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Battersby RJ; Women's and Children's Hospital, Adelaide, South Australia, Australia.
Ngui KM; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Penno MAS; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Colman PG; Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Craig ME; Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.; School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Barry SC; Women's and Children's Hospital, Adelaide, South Australia, Australia.; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Tran CD; CSIRO, Health and Biosecurity, Adelaide, South Australia, Australia.
Makrides M; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.; SAHMRI Women and Kids, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Harrison LC; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Couper JJ; Women's and Children's Hospital, Adelaide, South Australia, Australia.; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Źródło:: Pediatric diabetes [Pediatr Diabetes] 2021 May; Vol. 22 (3), pp. 425-433. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Copenhagen : Munksgaard, c2000-
MeSH Terms:: Diet*
Gastrointestinal Microbiome*
Autoimmunity/*physiology
Diabetes Mellitus, Type 1/*metabolism
Fatty Acids, Volatile/*metabolism
Islets of Langerhans/*immunology
Adolescent ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Female ; Humans ; Male ; Surveys and Questionnaires
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Contributed Indexing:: Keywords: diet; gut microbiome; islet autoimmunity; short chain fatty acids; type 1 diabetes
Substance Nomenclature:: 0 (Fatty Acids, Volatile)
Entry Date(s):: Date Created: 20210120 Date Completed: 20220117 Latest Revision: 20220117
Update Code:: 20240105
DOI:: 10.1111/pedi.13178
PMID:: 33470492
: Czasopismo naukowe

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Aim: We aimed to characterize associations between diet and the gut microbiome and short chain fatty acid (SCFA) products in youth with islet autoimmunity or type 1 diabetes (IA/T1D) in comparison with controls.
Research Design and Methods: Eighty participants (25 diagnosed with T1D, 17 with confirmed IA, 38 sibling or unrelated controls) from the Australian T1D Gut Study cohort were studied (median [IQR] age 11.7 [8.9, 14.0] years, 43% female). A Food Frequency Questionnaire characterized daily macronutrient intake over the preceding 6 months. Plasma and fecal SCFA were measured by gas chromatography; gut microbiome composition and diversity by 16S rRNA gene sequencing.
Results: A 10 g increase in daily carbohydrate intake associated with higher plasma acetate in IA/T1D (adjusted estimate +5.2 (95% CI 1.1, 9.2) μmol/L p = 0.01) and controls (adjusted estimate +4.1 [95% CI 1.7, 8.5] μmol/L p = 0.04). A 5 g increase in total fat intake associated with lower plasma acetate in IA/T1D and controls. A 5% increase in noncore (junk) food intake associated with reduced richness (adjusted estimate -4.09 [95%CI -7.83, -0.35] p = .03) and evenness (-1.25 [95% CI -2.00, -0.49] p < 0.01) of the gut microbiome in IA/T1D. Fiber intake associated with community structure of the microbiome in IA/T1D.
Conclusions: Modest increments in carbohydrate and fat intake associated with plasma acetate in all youth. Increased junk food intake associated with reduced diversity of the gut microbiome in IA/T1D alone. These associations with the gut microbiome in IA/T1D support future efforts to promote SCFA by using dietary interventions.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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