The inhibitory effect of somatostatin on gastric motility in Suncus murinus.

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Tytuł:: The inhibitory effect of somatostatin on gastric motility in Suncus murinus.
Autorzy:: Sekiya H; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan.
Yokota N; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan.
Takemi S; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan.
Nakayama K; Research Center of Neurology, Discovery and Research, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Okada H; Discovery Technology Research Laboratories, Discovery and Research, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Sakai T; Saitama University, 255 Shimo-okubo, Sakura-ku, Saitama 338-8570, Japan.
Sakata I; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan.; Area of Life-NanoBio, Division of Strategy Research, Graduate School of Science and Engineering, Saitama University, 255 Shimo-okubo, Sakura-ku, Saitama 338-8570, Japan.
Źródło:: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi [J Smooth Muscle Res] 2020; Vol. 56 (0), pp. 69-81.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Hirosaki-shi : Dō Gakkai, Heisei 3 [1991]-
MeSH Terms:: Gastrointestinal Motility/*drug effects
Somatostatin/*pharmacology
Animals ; Depression, Chemical ; Female ; In Vitro Techniques ; Male ; Motilin/pharmacology ; Muscle Contraction/drug effects ; Muscle, Smooth/drug effects ; Myoelectric Complex, Migrating/drug effects ; Postprandial Period ; Shrews ; Somatostatin/physiology ; Somatostatin/therapeutic use
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Contributed Indexing:: Keywords: MMC (migrating motor contractions); Suncus murinus; motilin; somatostatin
Substance Nomenclature:: 51110-01-1 (Somatostatin)
52906-92-0 (Motilin)
Entry Date(s):: Date Created: 20210121 Date Completed: 20210716 Latest Revision: 20210716
Update Code:: 20240105
PubMed Central ID:: PMC7817339
DOI:: 10.1540/jsmr.56.69
PMID:: 33473062
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Gastric contractions show two specific patterns in many species, migrating motor contractions (MMC) and postprandial contractions (PPCs), that occur in the fasted and fed states, respectively. In this study, we examined the role of somatostatin (SST) in gastric motility both in vivo and in vitro using the Asian house shrew (Suncus murinus). We performed in vivo recordings of gastric motility and in vitro organ bath experiments using S. murinus, which was recently established as a small laboratory animal for use in tests of gastrointestinal motility. SST (1.65 µg kg -1 min -1 ) was intravenously administered during phase II of MMC and PPCs. Next, the effect of SST on motilin-induced gastric contractions at phase I of MMC was measured. Cyclosomatostatin (CSST), an SST receptor antagonist, was administered at the peak of phase III of MMC. In addition, the effect of SST (10 -11 -10 -9 M) on motilin-induced gastric contractions was evaluated using an organ bath experiment in vitro. In conscious, free-moving S. murinus, the administration of SST decreased the occurrence of the spontaneous phase II of MMC and PPCs. Pretreatment with SST and octreotide suppressed the induction of motilin-induced gastric contractions both in vivo and in vitro. Administration of CSST before the peak of spontaneous phase III contractions had no effect on gastric contractions. Endogenous SST is not involved in the regulation of gastric MMC and PPCs, but exogenous SST suppresses spontaneous gastric contractions. Thus, SST would be good for treating abnormal gastrointestinal motility disorders.

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