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Tytuł pozycji:

Protective Effect of Natural Products against Huntington's Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action.

Tytuł:
Protective Effect of Natural Products against Huntington's Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action.
Autorzy:
Lum PT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, 30450 Perak, Malaysia.
Sekar M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, 30450 Perak, Malaysia.
Gan SH; School of Pharmacy, Monash University Malaysia, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.
Bonam SR; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Université de Paris, Paris 75006, France.
Shaikh MF; Neuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, 47500 Selangor, Malaysia.
Źródło:
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Feb 03; Vol. 12 (3), pp. 391-418. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Original Publication: Washington, D.C. : American Chemical Society
MeSH Terms:
Biological Products*/pharmacology
Biological Products*/therapeutic use
Huntington Disease*/drug therapy
Neurodegenerative Diseases*/drug therapy
Neuroprotective Agents*/pharmacology
Neuroprotective Agents*/therapeutic use
Animals ; Disease Models, Animal ; Motor Activity ; Nitro Compounds/pharmacology ; Nitro Compounds/therapeutic use ; Propionates/pharmacology ; Propionates/therapeutic use ; Rats ; Rats, Wistar
Contributed Indexing:
Keywords: 3-nitropropionic acid; Huntington’s disease; herbal medicine; natural products; neurodegenerative; neuroprotective
Substance Nomenclature:
0 (Biological Products)
0 (Neuroprotective Agents)
0 (Nitro Compounds)
0 (Propionates)
Entry Date(s):
Date Created: 20210121 Date Completed: 20210618 Latest Revision: 20210618
Update Code:
20240105
DOI:
10.1021/acschemneuro.0c00824
PMID:
33475334
Czasopismo naukowe
Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of adult life, followed by a gradual occurrence of characteristic psychiatric disturbances and cognitive and motor dysfunction. To the best of our knowledge, there is no treatment available to completely mitigate the progression of HD. Among various therapeutic approaches, exhaustive literature reports have confirmed the medicinal benefits of natural products in HD experimental models. Building on this information, this review presents a brief overview of the neuroprotective mechanism(s) of natural products against in vitro / in vivo models of HD. Relevant studies were identified from several scientific databases, including PubMed, ScienceDirect, Scopus, and Google Scholar. After screening through literature from 2005 to the present, a total of 14 medicinal plant species and 30 naturally isolated compounds investigated against HD based on either in vitro or in vivo models were included in the present review. Behavioral outcomes in the HD in vivo model showed that natural compounds significantly attenuated 3-nitropropionic acid (3-NP) induced memory loss and motor incoordination. The biochemical alteration has been markedly alleviated with reduced lipid peroxidation, increased endogenous enzymatic antioxidants, reduced acetylcholinesterase activity, and increased mitochondrial energy production. Interestingly, following treatment with certain natural products, 3-NP-induced damage in the striatum was ameliorated, as seen histologically. Overall, natural products afforded varying degrees of neuroprotection in preclinical studies of HD via antioxidant and anti-inflammatory properties, preservation of mitochondrial function, inhibition of apoptosis, and induction of autophagy.

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