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Tytuł pozycji:

Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes.

Tytuł:
Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes.
Autorzy:
Vasileva LV; Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, Plovdiv, Bulgaria.
Savova MS; Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv, Bulgaria.
Tews D; Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Wabitsch M; Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Georgiev MI; Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, Plovdiv, Bulgaria; Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv, Bulgaria. Electronic address: .
Źródło:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 Mar; Vol. 149, pp. 112002. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: Exeter : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, c1982-
MeSH Terms:
Adipocytes/*drug effects
Cinnamates/*pharmacology
Depsides/*pharmacology
Inflammation/*drug therapy
Obesity/*pathology
Adipocytes/metabolism ; Adipogenesis/drug effects ; CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Cinnamates/chemistry ; Depsides/chemistry ; Gene Expression Regulation/drug effects ; Humans ; Inflammation/metabolism ; Lipolysis/drug effects ; Molecular Structure ; Oxidative Stress/drug effects ; Rosmarinic Acid
Contributed Indexing:
Keywords: Adipocytes; Anti-Adipogenic action; Inflammation; Obesity; Orlistat (PubChem CID: 3034010); Rosmarinic acid; Rosmarinic acid (PubChem CID: 5281792)
Substance Nomenclature:
0 (CCAAT-Enhancer-Binding Proteins)
0 (CEBPA protein, human)
0 (Cinnamates)
0 (Depsides)
Entry Date(s):
Date Created: 20210121 Date Completed: 20210706 Latest Revision: 20231213
Update Code:
20240105
DOI:
10.1016/j.fct.2021.112002
PMID:
33476690
Czasopismo naukowe
Chronic low-grade inflammation is a hallmark of obesity and its related metabolic disorders. At the same time signaling from pro-inflammatory factors such as transforming growth factor beta (TGF-β) or interleukin 17A (IL-17A) are proposed as crucial for the commitment of fibroblast progenitor cells towards adipogenic differentiation. Modulation of inflammation during adipogenic differentiation is incompletely explored as a potential approach to prevent metabolic disorders. Rosmarinic acid (RA) is a caffeic acid derivative known for its anti-inflammatory effects. Experimental studies of its activity on adipogenic factors or in vivo obesity models are, however, controversial and hence insufficient. Here, we investigated the anti-adipogenic action of RA in human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes. Gene expression levels of key players in adipogenesis and lipid metabolism were assessed. Furthermore, a molecular mechanism of action was proposed. The most prominent effect was found on the translation of C/EBPα, PPARγ and adiponectin, as well as on the modulation of TGF1B and IL17A. Interestingly, involvement of NRF2 signaling was identified upon RA treatment. In summary, our findings indicate that RA prevents inflammation and excessive lipid accumulation in human adipocytes. Data from the molecular analysis demonstrate that RA has potential for treatment of obesity and obesity-related inflammation.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

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