Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis.

Tytuł :
Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis.
Autorzy :
Choi JK; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, USA.; Department of Immunology, Jeonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea.
Egwuagu CE; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health, Bethesda, MD, USA. .
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2270, pp. 437-450.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,
MeSH Terms :
B-Lymphocytes, Regulatory/*pathology
Uveitis/*immunology
Uveitis/*therapy
Adoptive Transfer ; Animals ; Autoimmune Diseases/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes, Regulatory/cytology ; B-Lymphocytes, Regulatory/immunology ; Central Nervous System Diseases ; Disease Models, Animal ; Female ; Inflammation/pathology ; Interleukin-10/immunology ; Male ; Mice ; Mice, Inbred NOD ; T-Lymphocytes, Regulatory/immunology ; Uveitis/metabolism
References :
Nussenblatt RB (1990) The natural history of uveitis. Int Ophthalmol 14(5–6):303–308. (PMID: 10.1007/BF00163549)
Nussenblatt RB (1991) Proctor lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest Ophthalmol Vis Sci 32(13):3131–3141. (PMID: 1748544)
Wraith DC, Nicholson LB (2012) The adaptive immune system in diseases of the central nervous system. J Clin Invest 122(4):1172–1179. (PMID: 10.1172/JCI58648)
Streilein JW (2003) Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol 3(11):879–889. (PMID: 10.1038/nri1224)
Caspi RR (2010) A look at autoimmunity and inflammation in the eye. J Clin Invest 120(9):3073–3083. (PMID: 10.1172/JCI42440)
Vignali DA, Kuchroo VK (2012) IL-12 family cytokines: immunological playmakers. Nat Immunol 13(8):722–728. (PMID: 10.1038/ni.2366)
Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, Das Sarma J, Gran B, Zhang GX, Rostami A (2007) Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol 179(5):3268–3275. (PMID: 10.4049/jimmunol.179.5.3268)
Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grutzkau A, Grun JR, Horn K, Kuhl AA, Dorner T, Bar-Or A, Kaufmann SH, Anderton SM, Fillatreau S (2014) IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 507(7492):366–370. (PMID: 10.1038/nature12979)
Zundler S, Neurath MF (2015) Interleukin-12: functional activities and implications for disease. Cytokine Growth Factor Rev 26(5):559–568. (PMID: 10.1016/j.cytogfr.2015.07.003)
Wang X, Wei Y, Xiao H, Liu X, Zhang Y, Han G, Chen G, Hou C, Ma N, Shen B, Li Y, Egwuagu CE, Wang R (2016) A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in lupus-like mice. Eur J Immunol 46(6):1343–1350. (PMID: 10.1002/eji.201546095)
Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, Nussenblatt RB, Gery I, Lee YS, Egwuagu CE (2007) T(H)17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 13(6):711–718. (PMID: 10.1038/nm1585)
Choi JK, Dambuza IM, He C, Yu CR, Uche AN, Mattapallil MJ, Caspi RR, Egwuagu CE (2017) IL-12p35 inhibits Neuroinflammation and ameliorates autoimmune encephalomyelitis. Front Immunol 8:1258. (PMID: 10.3389/fimmu.2017.01258)
Dambuza IM, He C, Choi JK, Yu CR, Wang R, Mattapallil MJ, Wingfield PT, Caspi RR, Egwuagu CE (2017) IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease. Nat Commun 8(1):719. (PMID: 10.1038/s41467-017-00838-4)
Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV, Wingfield PT, Kim SH, Egwuagu CE (2014) Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med 20(6):633–641. (PMID: 10.1038/nm.3554)
Mattapallil MJ, Wawrousek EF, Chan CC, Zhao H, Roychoudhury J, Ferguson TA, Caspi RR (2012) The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 53(6):2921–2927. (PMID: 10.1167/iovs.12-9662)
Contributed Indexing :
Keywords: CNS autoimmune disease*; EAU*; IL-10*; IL-35*; Regulatory B cells*; Uveitis*; i35-Breg*
Substance Nomenclature :
130068-27-8 (Interleukin-10)
Entry Date(s) :
Date Created: 20210122 Date Completed: 20210402 Latest Revision: 20210402
Update Code :
20210403
DOI :
10.1007/978-1-0716-1237-8_23
PMID :
33479912
Czasopismo naukowe
Regulatory B cells (Bregs) that produce IL-35 and IL-10 (i35-Bregs) regulate central nervous system (CNS) autoimmune diseases including uveitis. In the mouse model of uveitis, i35-Breg cells suppress intraocular inflammation by inducing expansion of IL-10-producing B cells (B10), IL-10-producing T cells (Tregs), and IL-35-producing T cells (iT R 35), suggesting that i35-Bregs orchestrate an immune-suppressive milieu that regulates immunity during autoimmune diseases. In this chapter, we discuss uveitis and therapeutic challenges that necessitate the development of cell-based therapies for the treatment of these potentially blinding diseases that cause 10% visual handicap. We then describe the methods we set up for ex vivo generation of i35-Breg cells employed in i35-Breg immunotherapy in uveitis and in other CNS autoimmune diseases.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies