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Tytuł pozycji:

Photoperiodic changes in hippocampal neurogenesis and plasma metabolomic profiles in relation to depression-like behavior in mice.

Tytuł:
Photoperiodic changes in hippocampal neurogenesis and plasma metabolomic profiles in relation to depression-like behavior in mice.
Autorzy:
Taniguchi E; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Tashiro A; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Hattori A; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Furuse M; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Yasuo S; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. Electronic address: .
Źródło:
Behavioural brain research [Behav Brain Res] 2021 Apr 09; Vol. 403, pp. 113136. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
MeSH Terms:
Behavior, Animal*/physiology
Depression*/metabolism
Depression*/physiopathology
Hippocampus*/metabolism
Hippocampus*/physiopathology
Neurogenesis*/physiology
Neuronal Plasticity*/physiology
Photoperiod*
Seasonal Affective Disorder*/metabolism
Seasonal Affective Disorder*/physiopathology
Basic Helix-Loop-Helix Transcription Factors/*blood
Insulin-Like Growth Factor I/*metabolism
Nerve Tissue Proteins/*blood
POU Domain Factors/*blood
Animals ; Cell Differentiation/physiology ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL
Contributed Indexing:
Keywords: Brn-4; Depression-like behavior; NeuroD1; Neuronal differentiation; Neuroplasticity; Phospho-Akt
Substance Nomenclature:
0 (Basic Helix-Loop-Helix Transcription Factors)
0 (Nerve Tissue Proteins)
0 (Neurod1 protein, mouse)
0 (POU Domain Factors)
0 (insulin-like growth factor-1, mouse)
147258-09-1 (Pou3f4 protein, mouse)
67763-96-6 (Insulin-Like Growth Factor I)
Entry Date(s):
Date Created: 20210122 Date Completed: 20211227 Latest Revision: 20211227
Update Code:
20240105
DOI:
10.1016/j.bbr.2021.113136
PMID:
33482168
Czasopismo naukowe
Photoperiod alters affective behaviors and brain neuroplasticity in several mammalian species. We addressed whether neurogenesis and signaling pathways of insulin-like growth factor-I (IGF-I), a key modulator of neuroplasticity, are regulated by photoperiod in C57BL/6 J mice, a putative model of seasonal affective disorder. We also examined the effects of photoperiod on plasma metabolomic profiles in relation to depression-like behavior to understand a possible linkage between peripheral metabolism and behavior. Mice that were maintained under long-day conditions (LD) exhibited a higher number of 5-bromo-2'-deoxyuridine-positive cells and higher levels of astrocyte marker in the dentate gyrus of the hippocampus compared to that of mice under short-day conditions (SD). Plasma IGF-I levels and levels/expression of IGF-I signaling molecules in the hippocampus (Brn-4, NeuroD1, and phospho-Akt) involved in neuronal proliferation and differentiation were higher in the mice under LD. Metabolome analysis using plasma of the mice under LD and SD identified several metabolites that were highly correlated with immobility in the forced swim test, a depression-like behavior. Negative correlations with behavior occurred in the levels of 23 metabolites, including metabolites related to neurogenesis and antidepressant-like effects of exercise, metabolites in the biosynthesis of arginine, and the occurrence of branched chain amino acids. Three metabolites had positive correlations with the behavior, including guanidinosuccinic acid, a neurotoxin. Taken together, photoperiodic responses of neurogenesis and neuro-glial organization in the hippocampus may be involved in photoperiodic alteration of depression-like behavior, mediated through multiple pathways, including IGF-I and peripheral metabolites.
(Copyright © 2021 Elsevier B.V. All rights reserved.)

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