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Tytuł:
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Biodegradable nanoparticles from prosopisylated cellulose as a platform for enhanced oral bioavailability of poorly water-soluble drugs.
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Autorzy:
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Kenechukwu FC; Drug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria; Instituto de Macromoléculas Professora Eloisa Mano (IMA), Programa de Ciencia e Tecnologia de Polimeros, Centro de Tecnologia, Universidade Federal do Rio de Janeiro (UFRJ), Brazil. Electronic address: .
Dias ML; Instituto de Macromoléculas Professora Eloisa Mano (IMA), Programa de Ciencia e Tecnologia de Polimeros, Centro de Tecnologia, Universidade Federal do Rio de Janeiro (UFRJ), Brazil.
Ricci-Júnior E; Nanomedicines Unit, Facultade de Pharmacia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, Brazil.
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Źródło:
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Carbohydrate polymers [Carbohydr Polym] 2021 Mar 15; Vol. 256, pp. 117492. Date of Electronic Publication: 2020 Dec 19.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
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MeSH Terms:
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Administration, Oral*
Solubility*
Biocompatible Materials/*chemistry
Cellulose/*chemistry
Nanoparticles/*chemistry
Water/*chemistry
Animals ; Biological Availability ; Buffers ; Drug Carriers/chemistry ; Drug Compounding ; Drug Delivery Systems ; Drug Liberation ; Female ; Griseofulvin/chemistry ; Hydrogen Bonding ; Hydrogen-Ion Concentration ; Male ; Nanotechnology/methods ; Particle Size ; Rabbits
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Contributed Indexing:
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Keywords: Acetone (PubChem CID: 180); Acetonitrile (PubChem CID: 18373917); Enhanced oral bioavailability; Ethanol (PubChem CID: 702); Griseofulvin (PubChem CID: 441140); Griseofulvin-loaded nanoparticles; High shear homogenization-nanoprecipitation technique; Hydrochloric acid (PubChem CID: 313); Microcrystalline cellulose (MCC); Microcrystalline cellulose (PubChem CID: 14055602); Phosphotungstic acid (PubChem CID: 16212977); Polyethylene glycol 400 (PubChem CID: 78255); Propylene glycol (PubChem CID: 1030); Prosopis africanagum (PG); Prosopisylated cellulose; Sodium hydroxide (PubChem CID: 14798); Thermo-regulated coacervation
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Substance Nomenclature:
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0 (Biocompatible Materials)
0 (Buffers)
0 (Drug Carriers)
059QF0KO0R (Water)
32HRV3E3D5 (Griseofulvin)
9004-34-6 (Cellulose)
OP1R32D61U (microcrystalline cellulose)
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Entry Date(s):
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Date Created: 20210123 Date Completed: 20210520 Latest Revision: 20210520
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Update Code:
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20240105
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DOI:
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10.1016/j.carbpol.2020.117492
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PMID:
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33483021
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Bio-inspired nanotechnology-based strategies are potential platforms for enhanced dissolution and oral biovailability of poorly water-soluble drugs. In this study, a recently patented green biopolymer (Prosopis africana gum, PG) was compatibilized with microcrystalline cellulose (MCC), a conventional polysaccharide, via thermo-regulated coacervation to obtain PG-MCC (1:0, 1:1, 1:2, 2:1, and 0:1) rational blends and the nanoparticles developed with optimized (1:1) biocomposites (termed "prosopisylated cellulose") by combined homogenization-nanoprecipitation technique was engineered as a high circulating system for improved oral bioavailability of griseofulvin (GF), a model Biopharmaceutics Classification System (BCS) Class-II drug. The effects of biopolymer interaction on morphological and microstructural properties of drug-free biocomposites obtained were investigated by Fourier transform infra-red spectroscopy, scanning electron microscopy and x-ray diffractometry, while the physicochemical properties and in-vivo pharmacokinetics of GF-loaded nanoparticles were also ascertained. Optimized biocomposites revealed inter-molecular and intra-molecular hydrogen bonding between the hydroxyl group of MCC and polar components of PG, as well as reduction in crystallinity of MCC. Griseofulvin-loaded nanoparticles were stable, displayed particles with relatively smooth surfaces and average size of 26.18 ± 0.94 . nm, with zeta potential and polydispersity index of 32.1 ± 0.57 mV and 0.173 ± 0.06, respectively. Additionally, the nanoparticles showed good entrapment efficiency (86.51 ± 0.93 %), and marked improvement in griseofulvin dissolution when compared to free drug, with significantly (p < 0.05) higher GF release in basic than acidic PEG-reinforced simulated bio-microenvironments. Besides, x-ray diffractogram of GF-loaded nanoparticles showed amorphization with few characteristic peaks of GF while infra-red spectrum indicated broader principal peaks of GF and components compatibility. Furthermore, GF-loaded nanoparticles showed low plasma clearance with three-fold increase in systemic bioavailability of griseofulvin compared with free drug. These results showed that prosopisylated cellulose nanoparticles would be a facile approach to improve oral bioavailability of BCS class-II drugs and can be pursued as a new versatile drug delivery platform.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
