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Tytuł:
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Mucoadhesion and Mechanical Assessment of Oral Films.
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Autorzy:
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Alaei S; College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, United States.
Omidian H; College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, United States. Electronic address: .
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Źródło:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Apr 01; Vol. 159, pp. 105727. Date of Electronic Publication: 2021 Jan 21.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier Science B.V
Original Publication: Amsterdam ; New York : Elsevier, c1993-
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MeSH Terms:
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Mouth Mucosa*/metabolism
Pharmaceutical Preparations*/metabolism
Administration, Buccal ; Aged ; Biological Availability ; Child ; Drug Delivery Systems ; Humans
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Contributed Indexing:
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Keywords: Buccal Patches; Mechanical Property; Mucoadhesion; Oral Films; Texture Analyzer; Transmucosal Delivery
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Substance Nomenclature:
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0 (Pharmaceutical Preparations)
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Entry Date(s):
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Date Created: 20210123 Date Completed: 20210621 Latest Revision: 20210621
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Update Code:
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20240105
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DOI:
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10.1016/j.ejps.2021.105727
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PMID:
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33484813
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Aligned with efforts to overcome shortcomings of conventional oral dosage forms, mucoadhesive oral thin films have been the focus of drug development. Transmucosal drug delivery through oral cavity is a popular alternative to deliver many drugs due to several advantages over conventional oral delivery including greater bioavailability due to bypassing the first-pass effect and avoiding enzymatic or acid-related degradation in the gastrointestinal tract, faster onset of action, and better patient compliance particularly in geriatric and pediatric patients. Furthermore, among solid transmucosal delivery platforms, buccal and sublingual strips or patches are more attractive due to their flexibility, ease of administration, high patient compliance, and fast dissolution. They are also more stable compared to oral gels making them a desirable candidate to deliver many small and large molecules locally or systemically. Mucoadhesion and mechanical properties of oral films are crucial in their performance, and therefore ways to measure these properties are also similarly important. Since they are relatively new to the pharmaceutical market, there are currently no FDA-recommended or USP standard methods available to characterize such dosage forms. This review intends to cover and discuss various methods cited in the literature to measure and evaluate mucoadhesive and mechanical properties of oral films.
(Copyright © 2021. Published by Elsevier B.V.)