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Tytuł:
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SARS-CoV-2 seroconversion among 4040 Egyptian healthcare workers in 12 resource-limited healthcare facilities: A prospective cohort study.
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Autorzy:
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Mostafa A; Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: .
Kandil S; Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
El-Sayed MH; Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Clinical Research Center (MASRI-CRC), Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Girgis S; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hafez H; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Yosef M; Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Saber S; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ezzelarab H; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ramadan M; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Algohary E; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Ain Shams University Specialized Hospitals, Egypt.
Fahmy G; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Ain Shams University Specialized Hospitals, Egypt.
Afifi I; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Hassan F; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Elsayed S; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Reda A; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Fattuh D; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Mahmoud A; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Mansour A; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Sabry M; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Habeb P; Infection Control Unit, Ain Shams University Hospitals, Cairo, Egypt.
Ebeid FS; Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Clinical Research Center (MASRI-CRC), Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Elanwar A; Ain Shams University Specialized Hospitals, Egypt; Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Saleh A; Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mansour O; Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Omar A; Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
El-Meteini M; Department of Hepatobiliary Surgery & Liver Transplantation, Ain Shams Center for Organ Transplantation (ASCOT), Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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Źródło:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Mar; Vol. 104, pp. 534-542. Date of Electronic Publication: 2021 Jan 20.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
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MeSH Terms:
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Seroconversion*
COVID-19/*immunology
Health Personnel/*statistics & numerical data
SARS-CoV-2/*immunology
Academic Medical Centers ; Adult ; COVID-19 Testing ; Cohort Studies ; Egypt/epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Serologic Tests ; Young Adult
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References:
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Lancet Infect Dis. 2020 Sep;20(9):1051-1060. (PMID: 32539986)
Nat Med. 2020 Jul;26(7):1033-1036. (PMID: 32398876)
Am J Epidemiol. 2021 Jan 4;190(1):161-175. (PMID: 32870978)
J Clin Microbiol. 2020 Jul 23;58(8):. (PMID: 32381641)
JAMA Intern Med. 2020 Oct 1;180(10):1356-1362. (PMID: 32808970)
Pathog Dis. 2020 Apr 1;78(3):. (PMID: 32510562)
Lancet. 2020 Jul 25;396(10246):e6-e7. (PMID: 32653078)
Lancet Infect Dis. 2020 Sep;20(9):1034-1042. (PMID: 32422204)
Int J Epidemiol. 2021 Mar 3;50(1):50-61. (PMID: 33094320)
Lancet Public Health. 2020 Sep;5(9):e475-e483. (PMID: 32745512)
Mayo Clin Proc. 2020 Aug;95(8):1621-1631. (PMID: 32753137)
PLoS Med. 2020 Oct 1;17(10):e1003358. (PMID: 33001967)
Lancet Respir Med. 2020 Sep;8(9):885-894. (PMID: 32717210)
Clin Infect Dis. 2020 Nov 19;71(16):2027-2034. (PMID: 32221519)
PLoS Pathog. 2020 Sep 24;16(9):e1008817. (PMID: 32970782)
Lancet Infect Dis. 2021 Feb;21(2):168. (PMID: 32553187)
Emerg Infect Dis. 2021 Jan;27(1):. (PMID: 33021927)
Cochrane Database Syst Rev. 2020 Jun 25;6:CD013652. (PMID: 32584464)
JAMA. 2020 Jun 16;323(23):2424-2425. (PMID: 32407440)
Nat Med. 2020 Jun;26(6):845-848. (PMID: 32350462)
J Clin Virol. 2020 Sep;130:104575. (PMID: 32805631)
Nat Microbiol. 2020 Dec;5(12):1598-1607. (PMID: 33106674)
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Contributed Indexing:
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Keywords: COVID-19; SARS-CoV-2; asymptomatic; cohort; healthcare workers; seroconversion
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Entry Date(s):
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Date Created: 20210123 Date Completed: 20210423 Latest Revision: 20210612
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Update Code:
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20240105
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PubMed Central ID:
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PMC7817419
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DOI:
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10.1016/j.ijid.2021.01.037
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PMID:
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33484863
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Background: We examined Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) seroconversion incidence and risk factors 21 days after baseline screening among healthcare workers (HCWs) in a resource-limited setting.
Methods: A prospective cohort study of 4040 HCWs took place at 12 university healthcare facilities in Cairo, Egypt; April-June 2020. Follow-up exposure and clinical data were collected through online survey. SARS-CoV-2 testing was done using rapid IgM and IgG serological tests and reverse transcriptase-polymerase chain reaction (RT-PCR) for those with positive serology. Cox proportional hazards modelling was used to estimate adjusted hazard ratios (HR) of seroconversion.
Results: 3870/4040 (95.8%) HCWs tested negative for IgM, IgG and PCR at baseline; 2282 (59.0%) returned for 21-day follow-up. Seroconversion incidence (positive IgM and/or IgG) was 100/2282 (4.4%, 95% CI:3.6-5.3), majority asymptomatic (64.0%); daily hazard of 0.21% (95% CI:0.17-0.25)/48 746 person-days of follow-up. Seroconversion was: 4.0% (64/1596; 95% CI:3.1-5.1) among asymptomatic; 5.3% (36/686; 95% CI:3.7-7.2) among symptomatic HCWs. Seroconversion was independently associated with older age; lower education; contact with a confirmed case >15 min; chronic kidney disease; pregnancy; change/loss of smell; and negatively associated with workplace contact.
Conclusions: Most seroconversions were asymptomatic, emphasizing need for regular universal testing. Seropositivity was three-fold that observed at baseline. Cumulative infections increased nationally by a similar rate, suggesting HCW infections reflect community not nosocomial transmission.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
