Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude.

Tytuł:: Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude.
Autorzy:: Ybañez-Julca RO; Laboratorio de Farmacología Facultad de Farmacia y Bioquímica Universidad Nacional de Trujillo Trujillo Perú.
Asunción-Alvarez D; Laboratorio de Farmacología Facultad de Farmacia y Bioquímica Universidad Nacional de Trujillo Trujillo Perú.
Palacios J; Laboratorio de Bioquímica Aplicada Facultad de Ciencias de la Salud Universidad Arturo Prat Iquique Chile.
Nwokocha CR; Department of Basic Medical Sciences Faculty of Medical Sciences The University of the West Indies Kingston Jamaica.
Źródło:: Reproductive medicine and biology [Reprod Med Biol] 2020 Nov 11; Vol. 20 (1), pp. 88-95. Date of Electronic Publication: 2020 Nov 11 (Print Publication: 2021).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Tokyo : Japan Society for Reproductive Medicine
Original Publication: Tokyo : Japanese Society of Fertility and Sterility
References:: Reprod Med Biol. 2020 Nov 11;20(1):88-95. (PMID: 33488288)
Int J Gynaecol Obstet. 2000 Feb;68(2):159-61. (PMID: 10717825)
JAMA. 2017 Dec 12;318(22):2224-2233. (PMID: 29234814)
Plant Foods Hum Nutr. 2007 Jun;62(2):59-63. (PMID: 17333395)
J Reprod Dev. 2014 Mar 7;60(1):55-61. (PMID: 24334513)
Indian J Exp Biol. 2012 Oct;50(10):744-8. (PMID: 23214269)
Toxicol Mech Methods. 2016;26(1):67-73. (PMID: 26633045)
Prim Care. 2018 Dec;45(4):625-641. (PMID: 30401346)
Sci Rep. 2020 Feb 26;10(1):3458. (PMID: 32103034)
Exp Anim. 2015;64(1):81-9. (PMID: 25312504)
Pharmaceuticals (Basel). 2016 Aug 18;9(3):. (PMID: 27548190)
Brain Res. 2013 Feb 1;1493:90-8. (PMID: 23194835)
Am J Hum Biol. 1996;8(4):457-463. (PMID: 28557077)
Oxid Med Cell Longev. 2016;2016:2158971. (PMID: 26640612)
J Physiol. 2016 Sep 15;594(18):5093-104. (PMID: 26453842)
Int J Biol Macromol. 2017 Jun;99:63-70. (PMID: 28174084)
J Physiol. 1995 Dec 15;489 ( Pt 3):869-76. (PMID: 8788950)
J Cell Biochem. 2011 Jan;112(1):128-37. (PMID: 21053364)
Hepat Mon. 2015 Feb 09;15(2):e22633. (PMID: 25788954)
High Alt Med Biol. 2017 Jun;18(2):128-134. (PMID: 28326844)
High Alt Med Biol. 2017 Dec;18(4):372-383. (PMID: 28846044)
High Alt Med Biol. 2020 Mar;21(1):12-19. (PMID: 31855465)
J Ethnopharmacol. 2014 Feb 3;151(2):897-902. (PMID: 24333960)
Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):128-31. (PMID: 17482529)
Clin Chim Acta. 2005 Oct;360(1-2):81-6. (PMID: 15970279)
Neurochem Int. 2006 Dec;49(8):709-16. (PMID: 16911847)
Int J Biometeorol. 2018 Nov;62(11):2045-2055. (PMID: 30218203)
Evid Based Complement Alternat Med. 2012;2012:193496. (PMID: 21977053)
Indian J Pharmacol. 2014 Jul-Aug;46(4):416-9. (PMID: 25097281)
Food Chem. 2019 Aug 1;288:422-443. (PMID: 30902313)
Ann N Y Acad Sci. 1959 Nov 18;83:207-16. (PMID: 13844580)
Mol Cell Endocrinol. 2004 Jun 30;221(1-2):21-32. (PMID: 15223129)
Toxicology. 2002 Nov 15;180(2):107-19. (PMID: 12324188)
J Neuroimmunol. 2010 Feb 26;219(1-2):90-9. (PMID: 20096467)
Int J Gynaecol Obstet. 1996 Oct;55(1):49-58. (PMID: 8910083)
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1079-83. (PMID: 14980639)
Nat Rev Endocrinol. 2018 Apr;14(4):199-215. (PMID: 29393299)
Sci Rep. 2018 Jul 26;8(1):11247. (PMID: 30050124)
Forsch Komplementmed. 2010;17(3):137-43. (PMID: 20616517)
J Appl Physiol (1985). 2001 Oct;91(4):1791-9. (PMID: 11568164)
Fertil Steril. 1967 May-Jun;18(3):396-419. (PMID: 6024083)
Oxid Med Cell Longev. 2018 Jul 26;2018:8989676. (PMID: 30147836)
J Food Sci. 2017 Mar;82(3):757-764. (PMID: 28231388)
Toxicology. 2002 Dec 27;181-182:219-22. (PMID: 12505314)
BMC Complement Altern Med. 2006 Jun 23;6:23. (PMID: 16796734)
Contributed Indexing:: Keywords: Lepidium meyenii; hormone replacement therapy; hypoxia; ovariectomy; oxidative stress
Entry Date(s):: Date Created: 20210125 Latest Revision: 20240330
Update Code:: 20240330
PubMed Central ID:: PMC7812464
DOI:: 10.1002/rmb2.12357
PMID:: 33488288
: Czasopismo naukowe

Pełny tekst

Purpose: Hormone Replacement Therapy (HRT) and herbal remedies are often used to alleviate menopausal symptoms, but their effects and efficacy at high altitudes presents with several uncertainties. The purpose of this study was to evaluate whether pre-treatment with maca ( Lepidium meyenii Walp) improved the tolerance to high altitude on an ovariectomized (OVX) rat model at sea level.
Method: The animals were treated with 17β-estradiol (200 µg/kg; E2), red and black maca (1.5 g/kg) for 28 days and exposed at high altitude or sea level.
Result: Our findings showed that red and black maca extracts significantly ( P < .001) reduced the MDA level in OVX rat serum under hypoxia in a similar way to E2. Red and black maca extracts had similar effects with E2, by significantly ( P < .001) reversing and increasing the ovariectomized induced decrease in cornified endometrial cell number. Under hypoxic conditions, the black maca ( P < .05) and E2 ( P < .01) increased the uterine weight in OVX rats. Finally, E2 alone significantly recovered the frequency of the uterine contractile response.
Conclusion: Aqueous extract of L. meyenii partially protects the reproductive function in hypobaric hypoxic environment, through the recovery of the cornified endometrial cells and uterine weight in a menopausal model of OVX rats.
Competing Interests: Roberto O. Ybañez‐Julca, Daniel Asunción‐Alvarez, Javier Palacios, and Chukwuemeka R. Nwokocha declare that they have no conflict of interest.
(© 2020 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.)

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja