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Tytuł pozycji:

Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular targets, primarily for synthetic and natural drugs targeting oncology therapeutics.

Tytuł :
Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular targets, primarily for synthetic and natural drugs targeting oncology therapeutics.
Autorzy :
Kaur I; Chitkara College of Pharmacy, Chitkara University, Punjab. India.
Behl T; Chitkara College of Pharmacy, Chitkara University, Punjab. India.
Sachdeva M; Fatima College of Health Sciences, Al Ain. United Arab Emirates.
Bungau S; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea. Romania.
Venkatachalam T; JKKMMRF College of Pharmacy, Tamilnadu. India.
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Źródło :
Current molecular pharmacology [Curr Mol Pharmacol] 2021 Jan 20. Date of Electronic Publication: 2021 Jan 20.
Publication Model :
Ahead of Print
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers
Contributed Indexing :
Keywords: Anti-cancer drugs; Extrinsic; Intrinsic; Mitochondria; Molecular targets; Programmed cell death; apoptosis signaling
Entry Date(s) :
Date Created: 20210126 Latest Revision: 20210126
Update Code :
20210210
DOI :
10.2174/1874467214666210120145537
PMID :
33494688
Czasopismo naukowe
The role of mitochondria in apoptosis signaling cell death pathway is regulated by extrinsic and intrinsic pathway, encompassing multiple components like Bcl-2 family of proteins, death receptors, caspases, Smac/DIABLO, IAPs, Omi/HtrA2 and cytochrome c. These entities serve as effective molecular targets for numerous drugs targeting mitochondrial apoptotic pathway, mainly emphasizing on oncology therapeutics. Defective apoptosis is an acquired hallmark of cancer cells, which promotes establishment of apoptosis-targeting anti-cancer drugs in cancer treatment. The review provides an overview of the Bcl-2 inhibiting, IAPs antagonizing, caspase inhibiting and BH3 mimicking actions, mediated by anti-cancer drugs, rendering beneficial outcomes in different forms of cancer. The authors elaborate the significance of synthetic and natural agents, targeting the mitochondrial apoptotic pathway, in ameliorating tumor cell growth in the body, and the specificity and effectiveness of these agents, motivating the researchers to explore mitochondrial apoptosis targeting of anti-tumor drugs, of both herbal and synthetic origin. Thus, the review aims to prognosticate this dynamic approach in oncology, simultaneously highlighting the challenges and future prospects, providing an opportunity to the experts, to "go over with a fine tooth comb" in understanding this "programmed cell death pathway", and establishing reliability and accuracy of this therapeutic paradigm in the upcoming future.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

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