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Tytuł:
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Variable seasonal influenza vaccine effectiveness across geographical regions, age groups and levels of vaccine antigenic similarity with circulating virus strains: A systematic review and meta-analysis of the evidence from test-negative design studies after the 2009/10 influenza pandemic.
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Autorzy:
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Okoli GN; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; George and Fay Yee Centre for Healthcare Innovation, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Vaccine and Drug Evaluation Centre, University of Manitoba, Winnipeg, MB, Canada.
Racovitan F; Vaccine and Drug Evaluation Centre, University of Manitoba, Winnipeg, MB, Canada.
Abdulwahid T; George and Fay Yee Centre for Healthcare Innovation, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Righolt CH; Vaccine and Drug Evaluation Centre, University of Manitoba, Winnipeg, MB, Canada; Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Mahmud SM; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Vaccine and Drug Evaluation Centre, University of Manitoba, Winnipeg, MB, Canada; Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Electronic address: .
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Źródło:
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Vaccine [Vaccine] 2021 Feb 22; Vol. 39 (8), pp. 1225-1240. Date of Electronic Publication: 2021 Jan 22.
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Typ publikacji:
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Journal Article; Meta-Analysis; Review; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam, The Netherlands : Elsevier Science
Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983-
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MeSH Terms:
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Influenza A Virus, H1N1 Subtype*
Influenza Vaccines*
Influenza, Human*/epidemiology
Influenza, Human*/prevention & control
Case-Control Studies ; Humans ; Influenza A Virus, H3N2 Subtype ; Influenza B virus ; Seasons ; Sentinel Surveillance
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Contributed Indexing:
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Keywords: Meta-analysis; Seasonal influenza; Systematic review; Test-negative design; Vaccine effectiveness
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Substance Nomenclature:
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0 (Influenza Vaccines)
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Entry Date(s):
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Date Created: 20210126 Date Completed: 20210521 Latest Revision: 20210521
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Update Code:
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20240105
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DOI:
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10.1016/j.vaccine.2021.01.032
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PMID:
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33494964
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Background: We examined the influence of some factors on seasonal influenza vaccine effectiveness (VE) from test-negative design (TND) studies.
Methods: We systematically searched for full-text publications of VE against laboratory-confirmed influenza from TND studies in outpatient settings after the 2009/10 influenza pandemic. Two reviewers independently selected and extracted data from the included studies. We calculated pooled adjusted VE across geographical regions, age groups and levels of vaccine antigenic similarity with circulating virus strains, using an inverse variance, random-effects model.
Results: We included 76 full-text articles from 11,931 citations. VE estimates against A(H1N1)pdm09, A(H3N2), influenza B, and all influenza were homogenous and point pooled VE higher in the Southern hemisphere compared with the Northern hemisphere. The difference in pooled VE between the Southern and Northern hemispheres was statistically significant for A(H3N2), influenza B, and all influenza. A consistent pattern was observed in pooled VE across both hemispheres and continents, with the highest point pooled VE being against A(H1N1)pdm09, followed by influenza B, and lowest against A(H3N2). A nearly consistent pattern was observed in pooled VE across age groups in the Northern hemisphere, with pooled VE mostly decreasing with age. Point pooled VE against A(H3N2), influenza B, and all influenza were statistically significantly higher when vaccine was antigenically similar to circulating virus strains compared with when antigenically dissimilar. Similar pattern was observed in the Northern hemisphere, but there was a lack of data from the Southern hemisphere.
Conclusion: Consistent patterns appear to exist in seasonal influenza VE across regions, age groups, and levels of vaccine antigenic similarity with circulating virus strains, with best vaccine performance against A(H1N1)pdm09 and worst against A(H3N2). The evidence highlights the need to consider geographical location, age, and vaccine antigenic similarity with circulating virus strains when designing and evaluating influenza VE studies.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. S. M. Mahmud has received unrestricted research grants from GlaxoSmithKline, Merck, Sanofi Pasteur, Pfizer and Roche-Assurex for unrelated studies, and fees as an advisory board member for Sanofi Pasteur. The other authors have no conflicts of interest to declare.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
