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Tytuł pozycji:

Whole-body x-ray dark-field radiography of a human cadaver.

Tytuł:
Whole-body x-ray dark-field radiography of a human cadaver.
Autorzy:
Andrejewski J; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany. .
De Marco F; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Willer K; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Noichl W; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Gustschin A; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Koehler T; Philips Research, 22335, Hamburg, Germany.
Meyer P; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany.
Kriner F; Institut für Rechtsmedizin, Ludwig-Maximilians-Universität München, 80336, Munich, Germany.
Fischer F; Institut für Rechtsmedizin, Ludwig-Maximilians-Universität München, 80336, Munich, Germany.
Braun C; Institut für Rechtsmedizin, Ludwig-Maximilians-Universität München, 80336, Munich, Germany.
Fingerle AA; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany.
Herzen J; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Pfeiffer F; Chair of Biomedical Physics, Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany.
Pfeiffer D; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany.
Źródło:
European radiology experimental [Eur Radiol Exp] 2021 Jan 26; Vol. 5 (1), pp. 6. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: [London, United Kingdom] : SpringerOpen, [2017]-
MeSH Terms:
Lung*
Cadaver ; Humans ; Phantoms, Imaging ; Radiography ; X-Rays
References:
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Contributed Indexing:
Keywords: Dark-field imaging; Human body; Radiography; Whole-body imaging; X-rays
Entry Date(s):
Date Created: 20210126 Date Completed: 20220202 Latest Revision: 20220202
Update Code:
20240105
PubMed Central ID:
PMC7835263
DOI:
10.1186/s41747-020-00201-1
PMID:
33495889
Czasopismo naukowe
Background: Grating-based x-ray dark-field and phase-contrast imaging allow extracting information about refraction and small-angle scatter, beyond conventional attenuation. A step towards clinical translation has recently been achieved, allowing further investigation on humans.
Methods: After the ethics committee approval, we scanned the full body of a human cadaver in anterior-posterior orientation. Six measurements were stitched together to form the whole-body image. All radiographs were taken at a three-grating large-object x-ray dark-field scanner, each lasting about 40 s. Signal intensities of different anatomical regions were assessed. The magnitude of visibility reduction caused by beam hardening instead of small-angle scatter was analysed using different phantom materials. Maximal effective dose was 0.3 mSv for the abdomen.
Results: Combined attenuation and dark-field radiography are technically possible throughout a whole human body. High signal levels were found in several bony structures, foreign materials, and the lung. Signal levels were 0.25 ± 0.13 (mean ± standard deviation) for the lungs, 0.08 ± 0.06 for the bones, 0.023 ± 0.019 for soft tissue, and 0.30 ± 0.02 for an antibiotic bead chain. We found that phantom materials, which do not produce small-angle scatter, can generate a strong visibility reduction signal.
Conclusion: We acquired a whole-body x-ray dark-field radiograph of a human body in few minutes with an effective dose in a clinical acceptable range. Our findings suggest that the observed visibility reduction in the bone and metal is dominated by beam hardening and that the true dark-field signal in the lung is therefore much higher than that of the bone.

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