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Tytuł pozycji:

Exploration of the risk factors of essential hypertension with hyperhomocysteinemia: A hospital-based study and nomogram analysis.

Tytuł:
Exploration of the risk factors of essential hypertension with hyperhomocysteinemia: A hospital-based study and nomogram analysis.
Autorzy:
Wang J; Medical quality management office, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315040, China.; Physical examination center, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, 315040, China.
Du J; Medical quality management office, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315040, China.; Physical examination center, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, 315040, China.
Fan R; Medical quality management office, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315040, China.
Źródło:
Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2021 Jan 20; Vol. 76, pp. e2233. Date of Electronic Publication: 2021 Jan 20 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
MeSH Terms:
Hyperhomocysteinemia*/complications
Hyperhomocysteinemia*/epidemiology
Hypertension*/complications
Hypertension*/epidemiology
Essential Hypertension ; Hospitals ; Humans ; Male ; Nomograms ; Risk Factors
References:
Clin Exp Hypertens. 2016;38(5):424-8. (PMID: 27359263)
Nutr J. 2015 Jan 10;14:6. (PMID: 25577237)
J Diabetes. 2016 Jan;8(1):38-40. (PMID: 26333161)
Clin Exp Hypertens. 2017;39(7):640-644. (PMID: 28640642)
Stat Med. 1996 Feb 28;15(4):361-87. (PMID: 8668867)
Am J Epidemiol. 2000 Jul 15;152(2):140-8. (PMID: 10909951)
Biomarkers. 2016 Sep;21(6):490-6. (PMID: 27008914)
Acta Diabetol. 2020 Jun;57(6):705-713. (PMID: 32008161)
Am J Clin Nutr. 2016 Jan;103(1):39-49. (PMID: 26675774)
Diabetes Res Clin Pract. 2018 Aug;142:286-293. (PMID: 29885388)
Free Radic Biol Med. 2013 Dec;65:1447-1454. (PMID: 23928335)
J Hum Hypertens. 2021 Jan;35(1):74-84. (PMID: 32107452)
Clin Nutr. 2017 Oct;36(5):1215-1230. (PMID: 27908565)
Stat Med. 2004 Jul 15;23(13):2109-23. (PMID: 15211606)
J Transl Int Med. 2015 Oct-Dec;3(4):171-178. (PMID: 27847909)
J Urol. 2013 May;189(5):1662-9. (PMID: 23103802)
J Hypertens. 2003 Jun;21(6):1011-53. (PMID: 12777938)
Endocrine. 2020 Mar;67(3):561-568. (PMID: 31820309)
J Clin Oncol. 2008 Mar 10;26(8):1364-70. (PMID: 18323559)
Clin Exp Hypertens. 2017;39(2):160-167. (PMID: 28287885)
Clin Exp Hypertens. 2018;40(5):495-500. (PMID: 29172835)
Entry Date(s):
Date Created: 20210127 Date Completed: 20210426 Latest Revision: 20220629
Update Code:
20240105
PubMed Central ID:
PMC7798116
DOI:
10.6061/clinics/2021/e2233
PMID:
33503187
Czasopismo naukowe
Objectives: To explore the risk factors of essential hypertension with hyperhomocysteinemia (H-type hypertension) and design a nomogram to predict this risk.
Methods: A hospital-based study was conducted on 1,712 individuals, including 282 patients with H-type hypertension, 105 patients with simple hypertension, 645 individuals with hyperhomocysteinemia, and 680 healthy controls. Logistic regression and nomogram models were applied to evaluate the risk factors.
Results: Logistic regression showed that advanced age, male sex, high body mass index (BMI), high total cholesterol levels, high glucose levels, and high creatinine levels were risk factors of H-type hypertension in the healthy population and were integrated into the nomogram model. Advanced age, male sex, high BMI, high total cholesterol levels, and high glucose levels were shown to be risk factors of H-type hypertension in the hyperhomocysteinemia population. Male sex and high creatinine levels were shown to be risk factors of H-type hypertension in the hypertension population. Nomogram analysis showed that the total factor score ranged from 106 to 206, and the corresponding risk rate ranged from 0.05 to 0.95.
Conclusions: Men are more likely to have H-type hypertension, and advanced age, high BMI, high total cholesterol levels, and high glucose levels are risk factors of H-type hypertension in healthy and hyperhomocysteinemia populations. Furthermore, high creatinine level is a risk factor of H-type hypertension in healthy and hypertension populations. Nomogram models may be used to intuitively evaluate H-type hypertension risk and provide a basis for personalized interventions.

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