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Tytuł pozycji:

The influence of PM 2.5 exposure on non-alcoholic fatty liver disease.

Tytuł :
The influence of PM 2.5 exposure on non-alcoholic fatty liver disease.
Autorzy :
Chen J; School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China.
Wu L; School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China.
Yang G; Department of Food Nutrition & Safety, School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China.
Zhang C; Department of Food Nutrition & Safety, School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China.
Liu X; Department of Food Nutrition & Safety, School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China.
Sun X; Occupational and Environmental Health Department, Global Health Research Center, Dalian Medical University, Dalian, PR China.
Chen X; Department of Epidemiology, School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China.
Wang N; Department of Food Nutrition & Safety, School of Public Health, Dalian Medical University, Dalian, Liaoning, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 119135. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
MeSH Terms :
Non-alcoholic Fatty Liver Disease/*etiology
Non-alcoholic Fatty Liver Disease/*physiopathology
Particulate Matter/*adverse effects
Air Pollutants/adverse effects ; Humans ; Lipid Metabolism/drug effects ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism
Contributed Indexing :
Keywords: Fine particulate matter (PM2.5); Non-alcoholic fatty liver disease (NAFLD); Pathogenesis
Substance Nomenclature :
0 (Air Pollutants)
0 (Particulate Matter)
Entry Date(s) :
Date Created: 20210129 Date Completed: 20210316 Latest Revision: 20210316
Update Code :
20210317
DOI :
10.1016/j.lfs.2021.119135
PMID :
33513397
Czasopismo naukowe
Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter < 2.5 μm, PM2.5) and the incidence of non-alcoholic fatty liver disease (NAFLD). By referring to previous studies on the pathogenesis of NAFLD and PM2.5 exposure-induced metabolic damage, we summarized the possible mediating pathways through which PM2.5 exposure can cause the phenotype and progression of NAFLD. Crucially, PM2.5 exposure is considered to have an impact on the classic hypothesis "multiple hits" of NAFLD. In addition, we also concluded that exposure to PM2.5 can promote the development of NAFLD by destroying the intestinal epithelium and microbiotic homeostasis, triggering endoplasmic reticulum stress, inducing abnormal expression of specific microRNA or inflammatory factors.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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