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Tytuł pozycji:

Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.

Tytuł:
Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction.
Autorzy:
Yang L; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China.
Li S; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China.
Mo C; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China.
Zhou B; Department of Poultry Breeding, Beijing Huadu Yukou Poultry Industry Co. Ltd., Beijing 100000 China.
Fan S; Department of Poultry Breeding, Beijing Huadu Yukou Poultry Industry Co. Ltd., Beijing 100000 China.
Shi F; Department of Poultry Breeding, Beijing Huadu Yukou Poultry Industry Co. Ltd., Beijing 100000 China.
Wei X; Department of Poultry Breeding, Beijing Huadu Yukou Poultry Industry Co. Ltd., Beijing 100000 China.
Zhao Q; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China.
Yang G; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China.
Li S; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China.
Mou C; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province 430070 China. Electronic address: .
Źródło:
Poultry science [Poult Sci] 2021 Mar; Vol. 100 (3), pp. 100892. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2020- : [Cambridge, UK] : Elsevier
Original Publication: Champaign Il : Poultry Science Association
MeSH Terms:
Chickens*/genetics
Fertility*/genetics
Gene Expression Profiling*/veterinary
Spermatozoa*
Age Factors ; Animals ; Female ; Insemination, Artificial/veterinary ; Male ; Oviducts/physiology ; Transcriptome/genetics
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Contributed Indexing:
Keywords: aging; breeder; chicken; sperm storage; uterovaginal junction
Entry Date(s):
Date Created: 20210131 Date Completed: 20210429 Latest Revision: 20210429
Update Code:
20240104
PubMed Central ID:
PMC7936153
DOI:
10.1016/j.psj.2020.12.005
PMID:
33516476
Czasopismo naukowe
Avian sperm storage tubules (SSTs), which are located in the uterovaginal junction (UVJ) of the oviduct, are primary sperm storage sites after mating or artificial insemination. The mechanism underlying reduced sperm storage efficiency of SSTs which is highly correlated with decreased fertility rates in aged laying breeders remains largely unclear. Here, comparative transcriptomic analysis between the aged and young White Leghorn hens (120 vs. 30 wk) was applied to identify gene expression changes of UVJs containing SSTs. Bioinformatics analysis revealed 567 upregulated and 1998 downregulated differentially expressed genes. Gene ontology analysis was highly enriched in terms of immune system, cell adhesion, and cytoskeleton proteins. Kyoto Encyclopedia of Genes and Genomes analysis revealed 5 significant (P < 0.05) pathways including inositol phosphate and glycerophospholipid metabolism. β-Galactosidase staining of chicken UVJ sections suggested increased cell senescence via aging. Oil Red O staining and immunohistochemistry detection of ADFP both confirmed distribution of lipid droplets in SST cells with increased intensity in aged breeders. The lipid synthesis and metabolism-related genes represented by TFAP2 and PLD1 were differentially expressed in aged laying breeders. The upregulation of IL15 and downregulation of a large number of immune-related genes in aged breeders indicate altered immune homeostasis in UVJs and SSTs. The increased accumulation of lipids, and altered immunity homeostasis, combined with other factors (TJP1, MYL9, AFDN, and RPL13, etc.) are potentially dominant effectors to decrease the sperm storage efficiency and egg fertility in aged laying breeders.
(Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)

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