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Tytuł:
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Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells.
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Autorzy:
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Yamamoto J; AntiCancer Inc, San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Aoki Y; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Han Q; AntiCancer Inc, San Diego, CA, U.S.A.
Sugisawa N; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Sun YU; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Hamada K; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Nishino H; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Inubushi S; AntiCancer Inc, San Diego, CA, U.S.A.; Department of Surgery, University of California, San Diego, CA, U.S.A.
Miyake K; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Matsuyama R; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Bouvet M; Department of Surgery, University of California, San Diego, CA, U.S.A.
Endo I; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan .
Hoffman RM; AntiCancer Inc, San Diego, CA, U.S.A.; .; Department of Surgery, University of California, San Diego, CA, U.S.A.
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Źródło:
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Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 641-643.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens, Greece : Potamitis Press
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MeSH Terms:
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Cell Transformation, Neoplastic/*metabolism
Lung Neoplasms/*metabolism
Methionine/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/pathology ; Humans ; Lung Neoplasms/pathology ; Mice, Nude ; Signal Transduction ; Tumor Burden ; Mice
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Contributed Indexing:
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Keywords: Cancer; H460; lung cancer; methionine addiction; methionine independence; reversion; tumorigenicity
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Substance Nomenclature:
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AE28F7PNPL (Methionine)
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Entry Date(s):
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Date Created: 20210131 Date Completed: 20210208 Latest Revision: 20240226
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Update Code:
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20240226
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DOI:
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10.21873/anticanres.14815
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PMID:
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33517268
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Background/aim: Methionine addiction, a fundamental and general hallmark of cancer, is due to the excess use of methionine for transmethylation, and is described as the Hoffman-effect. Methionine-addicted cancer cells can revert at low frequency to methionine independence when selected under methionine-restriction. We report here that highly-malignant methionine-addicted H460 human lung-cancer cells, when selected for methionine independence, have greatly-reduced tumorigenic potential.
Materials and Methods: Methionine-addicted H460 parental cancer cells and methionine-independent revertant H460-R1 cells were injected in nude mice subcutaneously.
Results: When the parental H460 methionine-addicted cells were injected in nude mice at 2.5×10 5 , 1×10 5 and 5×10 4 , the cells could form tumors. In contrast, the H460-R1 methionine-independent revertant cells could not form tumors when the above-listed cell numbers were injected in nude mice.
Conclusion: There is a tight linkage between methionine addiction and malignancy.
(Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
