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Tytuł:
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Impact of progesterone on skin and hair in menopause - a comprehensive review.
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Autorzy:
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Gasser S; Department of Obstetrics and Gynecology, University Clinic Inselspital, Bern, Switzerland.
Heidemeyer K; Department of Dermatology, University Clinic Inselspital, Bern, Switzerland.
von Wolff M; Department of Obstetrics and Gynecology, University Clinic Inselspital, Bern, Switzerland.
Stute P; Department of Obstetrics and Gynecology, University Clinic Inselspital, Bern, Switzerland.
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Źródło:
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Climacteric : the journal of the International Menopause Society [Climacteric] 2021 Jun; Vol. 24 (3), pp. 229-235. Date of Electronic Publication: 2021 Feb 02.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: London : Informa Healthcare
Original Publication: New York : Parthenon Pub., c1998-
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MeSH Terms:
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Estrogen Replacement Therapy*
Hair/*drug effects
Menopause/*drug effects
Progesterone/*administration & dosage
Skin Aging/*drug effects
Administration, Oral ; Administration, Topical ; Female ; Humans ; Middle Aged
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Contributed Indexing:
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Keywords: Progesterone; anti-aging; hair; hormone therapy; menopause; skin; sleep
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Substance Nomenclature:
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4G7DS2Q64Y (Progesterone)
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Entry Date(s):
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Date Created: 20210202 Date Completed: 20211103 Latest Revision: 20211103
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Update Code:
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20240104
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DOI:
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10.1080/13697137.2020.1838476
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PMID:
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33527841
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In clinical practice, micronized progesterone (MP) is frequently recommended to treat signs and symptoms of skin and hair aging in menopausal women. The aim of this comprehensive review was to evaluate whether topically or systemically applied MP may effectively prevent or slow down signs of skin and hair aging. Three out of six identified studies reported an impact of MP on skin aging markers in menopausal women. Of these, two studies reported a benefit: one for topically applied MP, another for systemically applied combined menopausal hormone therapy (MHT) comprising MP as progestogen for endometrial protection. Tolerability and safety of MP were good. However, there was no study investigating the impact of MP on menopausal scalp hair. In conclusion, delay of skin aging comprises lifestyle adjustment, antioxidants, and several esthetic procedures. In menopausal women, MHT displays beneficial effects on skin aging. There is poor quality but promising scientific evidence for MP displaying anti-aging skin effects in menopausal women. However, good quality studies are needed.
