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Tytuł pozycji:

Measures of Adiposity and Risk of Testing Positive for SARS-CoV-2 in the UK Biobank Study.

Tytuł:
Measures of Adiposity and Risk of Testing Positive for SARS-CoV-2 in the UK Biobank Study.
Autorzy:
Christensen RAG; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Sturrock SL; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Arneja J; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Brooks JD; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Źródło:
Journal of obesity [J Obes] 2021 Jan 22; Vol. 2021, pp. 8837319. Date of Electronic Publication: 2021 Jan 22 (Print Publication: 2021).
Typ publikacji:
Journal Article; Retracted Publication
Język:
English
Imprint Name(s):
Original Publication: New York ; Cairo, Egypt : Hindawi Publishing Corporation, 2010-
MeSH Terms:
Adiposity*
Body Mass Index*
Waist Circumference*
COVID-19/*etiology
Obesity/*complications
Age Factors ; Aged ; Biological Specimen Banks ; COVID-19/epidemiology ; COVID-19/virology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Obesity, Abdominal ; Risk Factors ; SARS-CoV-2 ; United Kingdom/epidemiology
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Entry Date(s):
Date Created: 20210205 Date Completed: 20210215 Latest Revision: 20231110
Update Code:
20240104
PubMed Central ID:
PMC7841447
DOI:
10.1155/2021/8837319
PMID:
33542836
Czasopismo naukowe
Objective: To assess if body mass index (BMI) and high waist circumference (HWC) are associated with testing positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: 9,386 UK Biobank study participants tested for SARS-CoV-2 from March 16 th 2020 to June 29 th 2020 were analyzed. A forward model building approach was used to estimate adjusted risk ratios (RR) and 95% confidence intervals (95% CI). Analyses were stratified by age due to a significant first-order interaction between age and HWC.
Results: Approximately 17% ( n  = 1,577) of participants tested positive for SARS-CoV-2. BMI category had a linear association with testing positive for SARS-CoV-2 among participants <65 years ( RR  = 1.09, 95% CI 1.02-1.17). For participants ≥65 years, only obesity class II ( RR  = 1.38, 95% CI 1.10-1.74) had a significantly greater risk of testing positive for SARS-CoV-2 than those who were underweight/normal weight. While HWC was not associated with testing positive for SARS-CoV-2 in those <65 years, having an HWC was associated with an increased risk of testing positive for SARS-CoV-2 in participants ≥65 years ( RR  = 1.12, 95% CI 1.00-1.27).
Conclusion: The associations of BMI and HWC with testing positive for SARS-CoV-2 differed by age. Notably, HWC was associated with testing positive in those ≥65 years, but not those who were younger, independent of BMI. This suggests that measures of adiposity in addition to BMI may be used to identify older individuals at greater risk of testing positive for SARS-CoV-2.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2021 Rebecca A. G. Christensen et al.)
Retraction in: J Obes. 2022 Mar 18;2022:9848453. (PMID: 35342645)
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