Hepatitis C virus infection and risk factors among patients and health-care workers of Ain Shams University hospitals, Cairo, Egypt.

Tytuł:: Hepatitis C virus infection and risk factors among patients and health-care workers of Ain Shams University hospitals, Cairo, Egypt.
Autorzy:: Anwar WA; Faculty of Medicine, Department of Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt.
El Gaafary M; Faculty of Medicine, Department of Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt.
Girgis SA; Faculty of Medicine, Department of Clinical Pathology, Ain Shams University, Cairo, Egypt.
Rafik M; Faculty of Medicine, Department of Clinical Pathology, Ain Shams University, Cairo, Egypt.
Hussein WM; Faculty of Medicine, Department of Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt.
Sos D; Faculty of Medicine, Department of Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt.
Mossad IM; Faculty of Medicine, Department of Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt.
Fontanet A; Emerging diseases epidemiology Unit, Institut Pasteur, Paris, France.; PACRI Unit, Institut Pasteur, Conservatoire national des arts et métiers, Paris, France.
Temime L; PACRI Unit, Institut Pasteur, Conservatoire national des arts et métiers, Paris, France.; Modélisation, Epidémiologie et Surveillance des Risques Sanitaires (MESuRS), Conservatoire national des arts et métiers, Paris, France.
Źródło:: PloS one [PLoS One] 2021 Feb 08; Vol. 16 (2), pp. e0246836. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).
Typ publikacji:: Clinical Trial; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Health Personnel*
Hepacivirus*
Hepatitis C*/blood
Hepatitis C*/epidemiology
Hepatitis C*/transmission
Hospitals, University*
Occupational Exposure/*adverse effects
Aged ; Cross-Sectional Studies ; Egypt/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence
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Entry Date(s):: Date Created: 20210208 Date Completed: 20210803 Latest Revision: 20210803
Update Code:: 20240104
PubMed Central ID:: PMC7870060
DOI:: 10.1371/journal.pone.0246836
PMID:: 33556152
: Czasopismo naukowe

Pełny tekst

Background: Hospitals are suspected of playing a key role in HCV epidemic dynamics in Egypt. This work aimed at assessing HCV prevalence and associated risk factors in patients and health-care workers (HCWs) of Ain Shams University (ASU) hospitals in Cairo.
Methods: We included 500 patients admitted to the internal medicine or surgery hospital from February to July, 2017, as well as 50 HCWs working in these same hospitals. Participants were screened for anti-HCV antibodies and HCV RNA. A questionnaire was administered to collect data on demographic characteristics and medical/surgical history. For HCWs, questions on occupational exposures and infection control practices were also included.
Results: The overall prevalence of anti-HCV antibodies was 19.80% (95% CI: 16.54-23.52) among participating patients, and 8.00% (95% CI: 0.48-15.52) among participating HCWs. In HCWs, the only risk factors significantly associated with anti-HCV antibodies were age and profession, with higher prevalence in older HCWs and those working as cleaners or porters. In patients, in a multivariate logistic regression, age over 50 (aOR: 3.4 [1.9-5.8]), living outside Cairo (aOR: 2.1 [1.2-3.4]), admission for liver or gastro-intestinal complaints (aOR: 4.2 [1.8-9.9]), and history of receiving parenteral anti-schistosomiasis treatment (aOR: 2.7 [1.2-5.9]) were found associated with anti-HCV antibodies.
Conclusions: While HCV prevalence among patients has decreased since the last survey performed within ASU hospitals in 2008, it is still significantly higher than in the general population. These results may help better control further HCV spread within healthcare settings in Egypt by identifying at-risk patient profiles upon admission.
Competing Interests: The authors have declared that no competing interests exist.

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